多囊卵巢综合征中医证型与性激素水平、胰岛素抵抗关系的研究

目的观察多囊卵巢综合征（PCOS）中医证型与血清性激素、胰岛素抵抗水平关系,研究其相关性。方法91例PCOS患者分为肾虚组（30例）、痰湿阻滞组（20例）、血瘀组（18例）及肝郁气滞组（23例）。同时设25例正常体检者为正常对照组,测定血清雌二醇（E2）、促卵泡生成素（FSH）、促黄体生成素（LH）、催乳素（PRL）、孕酮（P）、睾酮（T）、空腹胰岛素（FINS）及空腹葡萄糖（FPG）,稳态模型胰岛素抵抗指数（HOMA-IR）。结果（1）T、LH、LH/FSH：肾虚及肝郁气滞组高于其他组（P〈0.05或P〈0.01）;（2）E2：各证型均低于对照组（P〈0.01）;（3）P：各证型与对照组比较无显著性差异（P〉0.05）。（4）PRL：肝郁气滞组和血瘀组高于其他组（P〈0.05或P〈0.01）。（5）FINS、HOMA-IR：痰湿阻滞组高于其他组（P〈0.01）。结论各证型PCOS上述指标存在差异,可作为辨证分型参考依据。

Study on Correlation of Syndrome Types of Chinese Medicine with Sex Hormone Level and Insulin Resistance in Polycystic Ovary Syndrome

Objective To explore the correlativity of syndrome types of Chinese medicine with serum sexual hormones and insulin resistance in polycystic ovary syndrome（PCOS）.Methods 91 cases of PCOS were divided into kidney deficiency group（30 cases）,retention of phlegm damp（20 cases）,blood stagnation group（18 cases）and liver qi stagnation group（23 cases）.Simultaneously,25 cases of normal outcomes in physical examination were selected to be normal control group.It was to test the levels of estradiol（E2）,follicule - stimulating hormone （ FSH ）, luteinizing hormone （ LH ）, prolactin （ PRL ）, progesterone （ P ）, testosterone （ T）, fasting insulin （FINS） and fasting plasma glucose （FPG） , as well as homeostasis model assessment - insulin resistance （ HOMA - IR）. Results （ 1 ） The levels of T, LH and LH/FSH in kidney deficiency and liver qi stagnation groups were higher than those in other groups（P 〈0.05 or P 〈0.01 ）. （2）The level of E2 in every syndrome type group was lower than that in control group（ P 〈0.01 ）. （3）There was not significant difference in P in comparison of every syndrome type group with control group （P 〉 0.05 ）. （4）The level of PRL in liver qi stagnation and blood stagnation groups was higher than that in other groups（ P 〈 0.05 or P 〈 0.01 ）. （5）The levels of FINS and HOMA -IR in retention of phlegm damp group were higher than those in other groups （ P 〈 0.01 ）. Conclusion The differences in above indexes present in every syndrome type of PCOS in comparison, which can be taken as the evidence in reference for syndrome differentiation.