| 妇科千金胶囊对SD孕鼠生殖功能及受胎能力影响的研究 |
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| 引用本文： | 赵新广,刘丹卓,尤昭玲,左之文,颜利玲.妇科千金胶囊对SD孕鼠生殖功能及受胎能力影响的研究[J].世界中西医结合杂志,2011,6(12):1028-1031. |
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| 作者姓名： | 赵新广 刘丹卓 尤昭玲 左之文 颜利玲 |
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| 作者单位： | 1. 湖南中医药大学,湖南,长沙,410007
2. 株洲千金药业股份有限公司,湖南,株洲,412003 |
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| 摘 要： | 目的探讨妇科千金胶囊对SD孕鼠生殖功能及受胎能力的影响,对其临床前生殖安全性进行探索性研究。方法采用妇科千金胶囊不同剂量分别对健康育龄SD孕鼠进行体内染毒,观察其受孕前后体重、摄食量、动情周期等相关指标变化,并观察其交配时间、吸收胎、活胎、死胎、生殖器官重量等情况。结果妇科千金胶囊不同剂量对亲本鼠交配率、交配时间及动情周期等,均未见明显影响（P〉0.05）。各剂量对亲本鼠受孕率、活胎率及生殖器官重量等情况,也未见有明显影响（P〉0.05）。亲本鼠生殖器官病理检查也未发现与药物有关的组织病理学变化。结论在该实验研究所确定的条件下,妇科千金胶囊在7.68 g.kg-1剂量范围内对健康育龄SD雌鼠生殖功能及受胎能力无明显生殖毒性。
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| 关 键 词： | 妇科千金胶囊 生殖毒性 安全性 |
Study on Reproductive Function and Fertility for SD Pregnant Rats Treated with Fuke Qianjin Capsules |
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| ZHAO Xin-guang,LIU Dan-zhuo,YOU Zhao-ling,ZUO Zhi-wen,YAN Li-ling.Study on Reproductive Function and Fertility for SD Pregnant Rats Treated with Fuke Qianjin Capsules[J].World Journal Of Integrated Traditional and Wesrern Medicine,2011,6(12):1028-1031. |
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| Authors: | ZHAO Xin-guang LIU Dan-zhuo YOU Zhao-ling ZUO Zhi-wen YAN Li-ling |
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| Institution: | ZHAO Xin-guang1,LIU Dan-zhuo1,YOU Zhao-ling2,ZUO Zhi-wen2,YAN Li-ling2(1.Hunan University of Traditional Chinese Medicine,Changsha Hunan 410007,2.Zhuzhou Qianjin Pharmaceutical Co.Ltd.,Zhuzhou Hunan 412003) |
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| Abstract: | Objective To explore the impact of fuke qianjin capsules on the reproductive function and fertility for SD pregnant rats and conduct the explorative study on the reproductive safety before clinic trial.Methods Fuke qianjin capsules of different dosages were used for in vivo contamination of SD healthy pregnant rats at reproductive age.The changes of relative indexes were observed before and after pregnancy such as the body weight,food intake and estrous cycle.Additionally,the mating time,absorptive fetus,li... |
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| Keywords: | Fuke Qianjin Capsules Reproductive Toxicity Safety |
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