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| 金柴抗病毒胶囊防治甲型H1N1流感病毒PR8株感染小鼠肺炎的实验研究 | |
| 引用本文： | 钟菊迎,崔晓兰,时宇静,郭姗姗,高英杰,金亚宏,曹洪欣.金柴抗病毒胶囊防治甲型H1N1流感病毒PR8株感染小鼠肺炎的实验研究[J].世界中西医结合杂志,2010,5(4):297-299,304. |
| 作者姓名： | 钟菊迎 崔晓兰 时宇静 郭姗姗 高英杰 金亚宏 曹洪欣 |
| 作者单位： | 1. 中国中医科学院中医基础理论研究所,北京,100700 2. 中国中医科学院中药研究所,北京,100700 3. 中国中医科学院,北京,100700 |
| 基金项目： | 国家"重大新药创制专项课题 |
| 摘 要： | 目的观察金柴抗病毒胶囊对甲型H1N1流感病毒PR8株感染小鼠肺炎的防治作用,为进一步临床应用提供依据。方法采用滴鼻感染正常小鼠和免疫低下小鼠建立流感病毒感染肺炎模型,分别采用治疗和预防性给药,观察给药后各组对小鼠肺指数、死亡率、生存时间的影响。结果①金柴抗病毒胶囊所试3个剂量组均可明显降低正常小鼠感染后和免疫低下小鼠感染后肺指数、减少死亡率并延长生存时间。②金柴抗病毒胶囊所试3个剂量组在降低以上两种动物模型肺指数、降低免疫低下小鼠感染后死亡率的作用方面与达菲比较,差异无统计学意义。结论金柴抗病毒胶囊对流感病毒感染有较好的治疗和预防作用。 |
| 关 键 词： | H1N1流感病毒 金柴抗病毒胶囊 肺炎 达菲 |
Effect of Kim Chai Anti-Viral Capsules on Prevention and Treatment of Influenza A H1N1 Virus(PR8)in Mice |
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| ZHONG Ju-ying,CUI Xiao-lan,SHI Yu-jing,GUO Shan-shan,GAO Ying-jie,JIN Ya-hong,CAO Hong-xin.Effect of Kim Chai Anti-Viral Capsules on Prevention and Treatment of Influenza A H1N1 Virus(PR8)in Mice[J].World Journal Of Integrated Traditional and Wesrern Medicine,2010,5(4):297-299,304. | |
| Authors: | ZHONG Ju-ying CUI Xiao-lan SHI Yu-jing GUO Shan-shan GAO Ying-jie JIN Ya-hong CAO Hong-xin |
| Institution: | ZHONG Ju-ying1,CUI Xiao-lan2,SHI Yu-jing2,GUO Shan-shan2,GAO Ying-jie2,JIN Ya-hong2,CAO Hong-xin3 (1.China Academy of Chinese Medical Sciences,Beijing 100700,2.Institute of Materia Medica,China Academy of Chinese Medical Sciences,3.China Academy of Chinese Medical Sciences,Beijing 100700) |
| Abstract: | Objective To investigate the effect of kim chai anti-viral capsules on prevention and treatment of influenza A H1N1 virus(PR8)in mice so as to provide evidences for clinical application.Methods The nasal dropping method was adopted to infect normal mice and the immunocompromised mice to establish pneumonia model of influenza viral infection.The treating and preventive medications were administered respectively.The impacts on pulmonary index,mortality and life span of mice were compared among groups after me... |
| Keywords: | Influenza A H1N1 Virus Kim Chai Anti-Viral Capsules Pneumonia Tamiflu |
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