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化浊行血汤治疗胰岛素抵抗及对血清炎症因子的影响
引用本文:张风霞,张铭,孙西庆,王新陆.化浊行血汤治疗胰岛素抵抗及对血清炎症因子的影响[J].世界中西医结合杂志,2013,8(4):393-394,402.
作者姓名:张风霞  张铭  孙西庆  王新陆
作者单位:张风霞 (山东中医药大学附属医院,山东,济南,250011); 张铭 (潍坊市中医院,山东,潍坊,261021); 孙西庆 (山东中医药大学附属医院,山东,济南,250011); 王新陆 (山东中医药大学附属医院,山东,济南,250011);
基金项目:国家国家中医药管理局中医学术流派传承工作室建设项目;潍坊市卫生局科研基金资助课题项目(2011-005)
摘    要:目的探讨化浊行血汤治疗2型糖尿病胰岛素抵抗(IR)的疗效及作用机制。方法将80例初诊2型糖尿病患者随机分为对照组与治疗组,两组均口服二甲双胍0.25~0.5 g,每日3次,治疗组在此基础上加服化浊行血汤,水煎服,每日1剂,分早、晚两次服用。观察两组患者治疗前后空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)及血清炎症因子包括C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]的变化情况,并进行相关分析。结果两组患者治疗后FPG、HOMA-IR、CRP、IL-6、TNF-α明显下降,治疗组下降更明显(P<0.05)。结论化浊行血汤治疗2型糖尿病胰岛素抵抗的疗效确切,其机制可能为降低了血清炎症因子的水平。

关 键 词:2型糖尿病  胰岛素抵抗  血清炎症因子  化浊行血汤

Impacts of Huazhuo Xingxue Decoction on Insulin Resistance and Serum Inflammatory Factors
ZHANG Feng-xia,ZHANG Ming,SUN Xi-qing,WANG Xin-lu.Impacts of Huazhuo Xingxue Decoction on Insulin Resistance and Serum Inflammatory Factors[J].World Journal Of Integrated Traditional and Wesrern Medicine,2013,8(4):393-394,402.
Authors:ZHANG Feng-xia  ZHANG Ming  SUN Xi-qing  WANG Xin-lu
Institution:ZHANG Feng- xia ,ZHANG Ming ,SUN Xi -qing ,WANG Xin- lu (1. Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan Shandong 250011;2. Weifang Chinese Medicine Hospital, Weifang Shandong 261021 )
Abstract:Objective To explore the efficacy and mechanism on insulin resistance of diabetes type 2 treated with huazhuo xingxue decoction. Methods Eighty patients of diabetes type 2 at the first visit were randomized into a control group and a treatment group. Metformin,0.25 -0.5 g was prescribed for oral ad- ministration in the two groups, three times a day. In the treatment group, on the basic treatment, huazhuo xingxue decoction was supplemented, 1 dose a day, taking separately in the morning and the evening. The lev- els of FPG, FINS and HOMA - IR as well as serum inflammatory factors ( CRP, IL - 6 and TNF - α) were ob- served before and after treatment for the patients in the two groups. The correlative analysis was conducted. Results The levels of FPG, FINS, HOMA - IR CRP, IL - 6 and TNF - α were reduced apparently after treatment for the patients in the two groups. The levels of those indexes were reduced more apparently in the treatment group( P 〈 0.05 ). Conclusion Huazhuo xingxue decoction has definite efficacy on insulin resist- ance of diabetes type 2 ,which is possibly caused by reducing serum inflammatory factors.
Keywords:Diabetes Type 2  Insulin Resistance  Serum Inflammatory Factors  Huazhuo Xingxue De-coction
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