| 硝酸酯类对老年单纯收缩期高血压的影响 |
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| 引用本文： | 白丽杰,王彦海,王素贤. 硝酸酯类对老年单纯收缩期高血压的影响[J]. 实用全科医学, 2010, 8(3): 309-310 |
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| 作者姓名： | 白丽杰 王彦海 王素贤 |
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| 作者单位： | 辽宁省沈阳医学院奉天医院心内科,110024 |
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| 摘 要： | 目的比较依那普利和氢氯噻嗪加用与不加用单硝酸异山梨酯（ISMN）两种方案对老年单纯收缩期高血压（ISH）的降压疗效及安全性。方法110O例轻、中度老年ISH患者，随机分为A组60例，给予ISMN缓释片（40mg／d）、依那普利（10mg／d）、氢氯噻嗪（12．5mg／d），晨顿服；B组50例，给予依那普利（10mg，每日2次），氢氯噻嗪（25mg／d），均治疗8周。治疗前后测动态血压、诊室血压、心率及生化指标。结果A组总有效率在诊室血压为91．67％，动态血压为86．12％；B组分别为80．00％和74．29％。24h昼夜平均收缩压下降A组大于B组；收缩压谷/峰比及平滑指数A组高于B组（谷／峰比：0．75，0．59；平滑指数：0．86，0．65）。两组比较差异有统计学意义（P〈0．05）。结论硝酸酯等三药联用。可以24h平稳降低轻、中度老年ISH患者的血压，好于常规两药联用，安全性良好。
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| 关 键 词： | 老年人 单纯收缩期高血压 单硝酸异山梨酯 |
Efficacy of Isosorbide Mononitrate in the Treatment of Elderly Patients with Isolated Systolic Hypertension |
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| BAI Li-jie,WANG Yan-hai,WANG Su-xian. Efficacy of Isosorbide Mononitrate in the Treatment of Elderly Patients with Isolated Systolic Hypertension[J]. Applied Journal Of General Practice, 2010, 8(3): 309-310 |
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| Authors: | BAI Li-jie WANG Yan-hai WANG Su-xian |
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| Affiliation: | BAI Li-jie,WANG Yan-hai,WANG Su-xian.Department of Cardiology,the Fengtian Hospital of Shenyang Medical College,Shenyang 110024,Liaoning,China |
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| Abstract: | Objective Evaluate the efficacy and safety of mononitrate combined with conventional anti-hypertensive treatment for elderly patients with isolated systolic hypertension(ISH).Methods 110 elderly patients with mild-to-moderate ISH were randomly divided into 2 groups.Patients in group A(n=60) were given isosorbide mononitrate 40 mg/d,enapril 10 mg/d hydrochlorothiazide 12.5 mg/d in the morning.Patients in group B(n=50) were given enapril 10 mg twice per day and hydrochlorothiazide 25 mg once daily.All the pat... |
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| Keywords: | Elderly Isolated systolic hypertension(ISH) Isosorbide mononitrate(ISMN) |
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