乳腺癌中C-erbB-2、ER和PR表达及意义

目的分析研究C-erbB-2、ER、PR在乳腺癌中的表达与转移及预后关系。方法用免疫组化法测定93例原发性乳腺癌C-erbB-2、ER、PR的表达情况。结果C-erbB-2、ER、PR阳性表达率分别为:40.9%(38/93)、47.3%(44/93)、55.9%(52/93)。C-erbB-2随着临床分期增加和腋窝淋巴结转移数目的增加,其阳性表达率亦增加,差异有显者性(P<0.05)。ER、PR阳性表达率随着临床分期的递增和腋窝淋巴结转移数目的增加而降低,差异无显著性(P>0.05)。ER、PR阳性表达率与C-erbB-2阳性表达呈负相关,差异无显著性(P>0.05)。结论C-erbB-2是判断乳腺癌预后的有效指标,ER、PR与临床分期及腋窝淋巴结转移有一定关系,联合检测C-erbB-2、ER、PR可指导临床综合治疗。

Expression of C-erbB-2、ER and PR in Primary Breast Carcinoma and Its Clinical Significance

Objective To investigate the expression of C-erbB-2?ER and PR and the relationships to the metastasis and prognosis of primary breast carcinoma. Methods The expression of C-erbB-2?ER and PR was detected by immunochemical s-p methods in 93 Cases of primary breast carcinoma. Results The expression of C-erbB-2?ER?PR were observed in 40.9%(38/93), 47.3%(44/93)?55.92%(52/93) respectively. The positive rates of C-erbB-2 increased with the number of metastasis lymph node and clinical stage, and there was a significant correlation(P<0.05).The positive rates of ER and PR decreased with the number of metastasis lymph node and clinical stage. and there wasn't significant correlation(P>0.05). ER and PR had a reverse correlation with the expression of C-erbB-2, but there wasn't significant difference(P>0.05). Conclusions The C-erbB-2 is an useful prognostic factor in patients with breast carcinoma. The expression of ER and PR is associated with the clinical stage and lymph node metastasis of breast carcinoma, but the correlativity isn't significant. The combined detection of C-erbB-2?ER and PR has important significance for clinical therapy.