白细胞介素-2在人早期乳腺癌组织中的表达及预后意义

目的 探讨白细胞介素-2（interleukin-2，IL-2） 在乳腺癌患者肿瘤组织中的表达与临床病理特征及预后的关系。 方法 回顾性收集2000 年1 月- 2002 年12 月在解放军总医院手术的130 例Ⅰ - Ⅲ期乳腺癌患者的临床资料及石蜡切片，用免疫组织化学法检测IL-2 蛋白的表达，分析IL-2 蛋白的表达与乳腺癌临床病理特征及预后的关系。 结果 IL-2 主要在乳腺癌间质淋巴细胞中表达。IL-2 间质细胞密度与T 分期呈负相关（P =0.025）。IL-2 间质细胞密度高表达组的无病生存期（disease free survival，DFS）（P =0.007）、无远处转移生存期（distant disease free survival，DDFS）（P =0.010） 均优于低表达组，IL-2 间质细胞密度分组是总生存期（overall survival，OS）（HR=0.301，P =0.059）、DFS（HR=0.156，P =0.012）、DDFS（HR=0.171，P =0.018）的独立预后预测因素。 结论 IL-2 在乳腺癌肿瘤组织中的表达情况具有预后预测价值。IL-2 表达水平低的乳腺癌患者复发转移风险与死亡风险较高。

Expression of IL-2 in human early breast cancer tissue and its prognostic value

Objective To study the relation between expression of IL-2 in breast cancer tissue and clinicopathological characteristics and prognosis of breast cancer. Methods Clinical data about 130 patients with stages Ⅰ - Ⅲ breast cancer admitted to our hospital from January 2000 to December 2002 were retrospectively analyzed and their paraffin sections were collected. Relation between expression of IL-2 detected with immunohistochemical staining and clinicopathological features and prognosis of breast cancer was analyzed. Results The IL-2 was mainly expressed in mesenchymal lymphocytes of breast cancer. The IL-2 expression levels of disease-free survival （DFS） and distant disease-free survival （DDFS） were significantly higher in high density IL-2 mesenchymal cells than in low density IL-2 mesenchymal cells （P 〈 0.05）. The overall survival （OS, HR=0.301, P =0.059）, DFS（HR=0.156, P =0.012）and DDFS（HR=0.171, P =0.018）were the independent predicting factors for high density IL-2 mesenchymal cells. Conclusion Expression of IL-2 in breast cancer tissue can predict the prognosis of breast cancer. Relapse and metastasis of breast cancer are related with the high death rate in breast cancer patients with a low IL-2 expression level.