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| 89例垂体柄中断综合征患者垂体-甲状腺轴激素特点分析 | |
| 引用本文： | 臧丽,张娟,郭清华,曹邓晗,杨国庆,金楠,谷伟军,陈康,杜锦.89例垂体柄中断综合征患者垂体-甲状腺轴激素特点分析[J].军医进修学院学报,2015,36(1):53-55. |
| 作者姓名： | 臧丽 张娟 郭清华 曹邓晗 杨国庆 金楠 谷伟军 陈康 杜锦 |
| 作者单位： | 1. 解放军总医院内分泌科,北京,100853 2. 河北省新乐市医院,河北新乐,050700 3. 郑州市第一人民医院,河南郑州,450004 |
| 基金项目： | 国家自然科学基金项目(81370871)Supported by the National Natural Science Foundation of China |
| 摘 要： | 目的分析垂体柄中断综合征(pituitary stalk interruption syndrome,PSIS)患者垂体-甲状腺轴激素特点。方法回顾性分析解放军总医院自2000-2013年收治的89例PSIS患者垂体-甲状腺轴激素特点。结果 89例中71例(79.78%)发生中枢性甲减,血清促甲状腺激素(thyroid stimulating hormone,TSH)为(5.42±3.67)m U/L;18例甲状腺功能正常,TSH为(3.66±1.50)m U/L。中枢性甲减患者中29例(40.85%)TSH高于正常(8.79±3.17)m U/L],38例(53.53%)在正常范围内(3.42±1.30)m U/L],4例(5.63%)低于正常范围(0.02±0.01)m U/L];TSH升高组血清游离T4(serum free T4,FT4)较TSH正常组略低,但差异无统计学意义(7.90±1.38)pmol/L vs(8.08±1.42)pmol/L,P>0.05)]。中枢性甲减伴TSH升高患者行甲状腺激素替代治疗后TSH降至正常(7.24±0.98)m U/L vs(1.67±1.51)m U/L]。PSIS患者TSH水平与垂体高度及垂体柄状态不相关(P>0.05)。结论 PSIS所致中枢性甲减患者TSH升高比例更高,升高幅度更大。PSIS患者TSH升高与垂体柄的状态及垂体前叶高度无关,其原因可能为甲状腺激素的反馈抑制作用减弱致使垂体TSH细胞分泌了无生物活性的TSH。 |
| 关 键 词： | 垂体柄中断综合征 中枢性甲减 促甲状腺激素 |
Characteristics of pituitary-thyroid axis in patients with pituitary stalk interruption syndrome: An analysis of 89 cases |
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| ZANG Li;ZHANG Juan;GUO Qinghua;CAO Denghan;YANG Guoqing;JIN Nan;GU Weijun;CHEN Kang;DU Jin;WANG Xianling;YANG Lijuan;BA Jianming;LYU Zhaohui;DOU Jingtao;MU Yiming.Characteristics of pituitary-thyroid axis in patients with pituitary stalk interruption syndrome: An analysis of 89 cases[J].Academic Journal of Pla Postgraduate Medical School,2015,36(1):53-55. | |
| Authors: | ZANG Li;ZHANG Juan;GUO Qinghua;CAO Denghan;YANG Guoqing;JIN Nan;GU Weijun;CHEN Kang;DU Jin;WANG Xianling;YANG Lijuan;BA Jianming;LYU Zhaohui;DOU Jingtao;MU Yiming |
| Institution: | ZANG Li;ZHANG Juan;GUO Qinghua;CAO Denghan;YANG Guoqing;JIN Nan;GU Weijun;CHEN Kang;DU Jin;WANG Xianling;YANG Lijuan;BA Jianming;LYU Zhaohui;DOU Jingtao;MU Yiming;Department of Endocrinology,Chinese PLA General Hospital;Department of Endocrinology,Xinle Hospital of Hebei Province;Department of Endocrinology,The First People’s Hospital of Zhengzhou; |
| Abstract: | |
| Keywords: | pituitary stalk interruption syndrome central hypothyroidism thyroid stimulating hormone |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |