| 新鲜冰冻血浆和冷沉淀对链脲佐菌素糖尿病大鼠的影响 |
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| 引用本文： | 汪德清,陈麟凤,李卉,于洋,王海宝,林子林,刘景汉.新鲜冰冻血浆和冷沉淀对链脲佐菌素糖尿病大鼠的影响[J].军医进修学院学报,2009,30(4):525-527. |
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| 作者姓名： | 汪德清 陈麟凤 李卉 于洋 王海宝 林子林 刘景汉 |
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| 作者单位： | 解放军总医院输血科全军临床输血中心,北京,100853 |
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| 摘 要： | 目的探讨血液成分新鲜冰冻血浆和冷沉淀对链脲佐菌素糖尿病大鼠的影响。方法将雄性Wistar大鼠分为空白对照组和糖尿病模型组，后者用链脲佐菌素（STZ）按一次性腹腔注射造模。造模成功后的大鼠随机分为3组：糖尿病模型组、新鲜冰冻血浆处理组和冷成淀处理组，每周称体重和测血糖各1次，6周后收集血液测定血糖、血清胰岛素、血脂和其他生化参数。结果STZ糖尿病大鼠血糖血脂显著高于空白对照组，胰岛素水平明显低于空白对照组；与实验组比较，新鲜冰冻血浆处理组和冷沉淀处理组的血糖和胰岛素的改变不具有统计学意义，但是新鲜冰冻血浆和冷沉淀能显著降低STZ引起的转氨酶升高（P〈0．05）。结论新鲜冰冻血浆和冷沉淀具有减轻STZ所致损伤的作用。
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| 关 键 词： | 糖尿病 大鼠 血浆 沉淀 链脲菌素 |
Effect of fresh frozen plasma and crytoprecipitate on diabetes induced by streptozocin in rats |
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| WANG De-qing,CHEN Lin-feng,LI Hui,YU Yang,WANG Hai-bao,LIN Zi-lin,LIU Jing-han.Effect of fresh frozen plasma and crytoprecipitate on diabetes induced by streptozocin in rats[J].Academic Journal of Pla Postgraduate Medical School,2009,30(4):525-527. |
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| Authors: | WANG De-qing CHEN Lin-feng LI Hui YU Yang WANG Hai-bao LIN Zi-lin LIU Jing-han |
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| Institution: | WANG De-qing,CHEN Lin-feng,LI Hui,YU Yang,WANG Hai-bao,LIN Zi-lin,LIU Jing-han Department of Blood Transfusion,Center of Clinical Transfusion of PLA,Chinese PLA General Hospital,Beijing 100853,China |
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| Abstract: | Objective To explore the effect of fresh frozen plasma(FFP) and crytoprecipitate(CRYO) on diabetes induced by streptozocin(STZ) in rats. Methods Male Wister rats were divvied into blank control group and diabetes model group. A diabetes model was established by intra-peritoneal injection of STZ(80mg/kg) .Then,the rats were randomly divided into diabetes model group,FFP group and CRYO group,with their weight and blood sugar level measured once a week. Levels of blood sugar,insulin,lipid,and other biochemistr... |
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| Keywords: | diabetes mellitus rats plasma precipitation streptozocin |
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