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内毒素致兔急性肺损伤及血必净保护作用
引用本文:孙军平,汪建新,郭丽娜.内毒素致兔急性肺损伤及血必净保护作用[J].军医进修学院学报,2009,30(1):102-104.
作者姓名:孙军平  汪建新  郭丽娜
作者单位:解放军总医院,呼吸内科,北京,100853
基金项目:解放军总医院创新基金 
摘    要:目的:观察内毒素(ET)致兔急性肺损伤(Au)时肺组织中丙二醛(MDA)含量及超氧化物岐化酶(SOD)活性的的变化,探讨血必净对急性肺损伤保护作用的机制。方法:将24只日本大耳白兔随机分为对照组(A组),内毒素致伤组(B组),内毒素致伤及血必净干预组(C组)。用内毒素(750μg/kg)一次性静脉注射方法复制兔ALI模型,应用血必净按1.8mL/kg静脉注射进行干预,分别检测肺组织中的MDA含量及SOD活性。结果:A组氧合指数保持稳定,B组在致伤后0.5h动物氧合指数显著下降,之后略有回升但仍低于基础水平,C组下将趋势低于B组。B组动物肺组织中MDA含量明显高于A组(P〈0.01)与C组(P〈0.05),A组、C组间无差别。B组肺组织SOD活性明显低于A组(P〈0.01)与C组(P〈0.05),A组、C组间无差别。肺组织病理学发现A组肺组织正常,B组出现渗出,淤血,炎细胞浸润等,C组病理损伤轻于B组。结论:血必净可以降低肺组织中MDA的含量和提高SOD的活性,该药对内毒素所致兔ALI有一定的保护作用。

关 键 词:急性呼吸窘迫综合症  成人  内毒素类  丙二醛  超氧化物岐化酶  血必净

Endotoxin-induced acute lung injury in rabbits and protective effect of Xuebijing
SUN Jun-ping,WANG Jian-xin,GUO Lina.Endotoxin-induced acute lung injury in rabbits and protective effect of Xuebijing[J].Academic Journal of Pla Postgraduate Medical School,2009,30(1):102-104.
Authors:SUN Jun-ping  WANG Jian-xin  GUO Lina
Institution:Respiratory Department;Chinese PLA General Hospital;Beijing 100853;China
Abstract:Objective: To investigate the changes of maleic dialdehyde (MDA) levels and superoxide dismutase (SOD) activities in the lung tissues of rabbits with eudotoxiu-induced acute lung injury (ALI) , and study the protective mechanism of xuebijing. Methods: 24 male Japanese flap-eared white rabbits were randomly divided into 3 groups: control group (Group A) , endotoxin-indueed ALl group (Group B) and xuebijing treatment group (Group C ). ALl models of the rabbits were replicated by intravascular ET injection (750p, g/kg), and xuebijing (1.8mL/kg weight)was intravascularly injected in xuebijing treatment group. Results: MDA levels in-Group B was significantly higher than in Group A(P 〈0.01) and Group C (P 〈0.05) , and there was no difference between Group A and Group C. SOD activities in Group B were lower than in Group A ( P 〈 0.01 ) and Group C ( P 〈 0.05 ) , and no difference was found between Group A and Group C. Conclusion: Xuebijing can significantly lower MDA levels and increase SOD activities in lung tissues. Xuebijing may have the effect of protecting rabbits with endotoxin-induced ALL
Keywords:acute respiratory distress syndrome  adult  endoxin  maleic dialdehyde  superoxide dismutase  xuebijing  
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