阿尔茨海默病11C-PIBPET连续动态显像结果分析

目的探讨11C—PIBPET脑内老年斑显像的显像条件；研究健康老年人（HC）与阿尔茨海默病（AD）的11C—PIBPET脑显像特点。方法严格筛选2组受试者，阿尔茨海默病（AD）患者组6例，健康对照（HC）组7例。每位受试者均采用连续动态采集程序采集脑PET图像。两名核医学医师视觉分析各组受试者的图像，总结成像特点。感兴趣方法（ROI）划取大脑皮层各叶和皮层下核团，得出各个脑区不同时间点的SUV值。并选取45min时间点的SUV值，计算出45min时各脑区与小脑的SUV比值。将计算得到的2组脑区／小脑比值进行统计学分析。结果11C—PIB能快速通过血脑屏障，且之后能很快从健康脑组织内洗脱。时间-放射性曲线显示AD患者脑内放射性清除较HC减慢。脑区／小脑比值AD与HC比较，除脑桥／小脑及白质／小脑外其余脑区与小脑的比值两组之间差异均具有统计学意义（t=4．06—7．28，P〈0．05）。结论11C—PIBPET脑显像是有效诊断AD的神经影像学工具。

11C-PIB PET dynamic imaging for patients with Alzheimer disease

Objective To study the conditions of HC-PIB PET dynamic imaging for intra-cranial senile plaques and the features of 11C-PIB PET imaging for healthy aged control subjects （HC） and Alzheimer disease （AD） patients. Methods 6 AD patients and 7 health control （HC） subjects were enrolled in this study. Sequential 11C-PIB PET imaging was performed for each subject. Features of the images obtained were analyzed by 2 physicians of nuclear medicine. The region of interest （ROI） was used to plot the cerebral cortex and infra-cortical nuclear diagram to calculate and analyze the SUN values for each brain region at different time points. Results 11C-PIB could rapidly pass through the blood-brain barrier and was then quickly cleared from healthy brain tissues. The time-radioactivity curve showed that the radioactivity was cleared at a lower speed in AD patients than in HC. The difference in ratio of brain region/cerebellum （except for pons / cerebellum and protein / other brain regions and cerebellum out of the cerebellum） between AD patients and HC was statistically significant （t=4.06-7.28, P〈0.05）. Conclusion 11C-PIB PET imaging is an effective tool for the diagnosis of AD.