胶质瘤1号和19号染色体多体与临床病理影像学因素的相关性

目的 研究与胶质瘤1号和19号染色体多体相关的临床、病理和影像学因素.方法 254例胶质瘤患者,应用荧光原位杂交法(FISH)检测肿瘤组织中染色体1p/19q缺失状态和染色体多体比率.染色体多体定义为肿瘤组织中30％以上的肿瘤细胞含有两个以上的1q和19p荧光信号.患者年龄、性别、肿瘤病理类型、级别和部位通过回顾分析病历和影像资料获得.通过单变量和多变量分析确定与1号和19号染色体相关的因素.结果 254例中,68(26.8％)例同时为1号和19号染色体多体,1号和19号染色体多体显著相关(P＜0.000 001).单变量和多变量分析显示1号和19号染色体多体与年龄小和1p/19q联合缺失相关,与性别、肿瘤病理类型、级别、肿瘤部位无关.结论 1号和19号染色体多体共存于胶质瘤中.1号和19号染色体多体不能用于预测病理类型和级别,年龄小和1p/19q联合缺失是与染色体多体相关的独立因素,提示染色体多体对良好预后可能存在预测作用.

Correlation between polysomy of chromosomes 1 and 19 in glioma and its clinicopathological and radiological factors

Objective To study the clinicopathological and radiological factors for polysomy of chromosomes 1 and 19 in patients with glioma.Methods Deletion of chromosomes 1p and 19q and their polysomy were detected in 254 patients with glioma by fluorescence in situ hybridization（FISH）.Polysomy of chromosome was defined as more than two 1q and 19p signals in 〉30% glioma cells.Other factors,including age and gender of patients with glioma,and pathology,grade and location of glioma,were obtained through a retrospective analysis of medical records and radiological imaging data.Factors for polysomy of chromosomes 1 and 19 were identified through univariate and multivariate analysis.Results Among the 254 patients with glioma,polysomy of chromosomes 1 and 19 was detected in 68（26.8%） with a significant correlation（P〈0.000 001）.Univariate and multivariate analysis showed that the polysomy of chromosomes 1 and 19 was significantly related with the younger age of glioma patients and deletion of chromosomes 1p and19q but not with their age and gender,glioma pathology,grade and location.Conclusion Polysomy of chromosomes 1 and 19 existing in glioma cannot be used to predict glioma pathology and grade.Younger age of glioma patients and deletion of chromosomes 1 and 19 are the independent factors for the polysomy of chromosomes 1 and 19,indicating that polysomy of chromosomes can be used as a predictor for the favorable prognosis of glioma.