ALA-PDT联合干扰素治疗鲍温样丘疹的临床观察

目的探讨5-氨基酮戊酸光动力(ALA-PDT)联合干扰素治疗鲍温样丘疹病(BP)的效果。方法收集2012年1月²013年12月间我院收治的70例BP患者资料,随机分为两组,每组35例。对照组采用干扰素进行治疗,观察组在干扰素的基础上联用ALA-PDT进行治疗。对两组治疗有效率、半年复发率及不良反应进行比较。结果治疗1个月后,观察组总有效率为91.43%(32/35),高于对照组的62.86%(22/35),差异有统计学意义(P<0.05);观察组半年复发率为5.71%(2/35),低于对照组的17.14%(6/35),差异无统计学意义(P>0.05);观察组不良反应率为11.43%(4/35),与对照组的25.71%(9/35)比较,差异无统计学意义(P>0.05)。结论 ALA-PDT联合干扰素临床治疗BP具有疗效好、复发率低的优点,值得推广。

Clinical observation on the efficacy of ALA-PDT combined with interferon for treatment Bowenoid papulosis

Objective To observe the efficacy of 5-aminolevulinic acid photodynamic therapy （ALA- PDT） combined with interferon in treatment of patients with Bowenoid papulosis. Methods Seventy patients with Bowenoid papulosis treated in our hospital from January 2012 to December 2013 were selected and randomly divided into 2 groups, each had 35 cases. Patients in control group were treated with ALA-PDT. Patients in observation group were treated with interferon based on the ALA-PDT. The efficiency, recurrence rate, adverse reaction of two groups were compared. Results One month after treatment, the effective rate of observation group was 91.43% （32/35）, which was higher than control group [62.86% （22/35）], there was statistically significant difference （ P 〈0. 05）. After 6 months treatment, the recurrence rate of observation groups was 5.71% （2/35）, which was lower than control group [17.14% （6/35）], but the difference was not statistically significant （ P 〉0.05）. The adverse reaction rate of 11.43% （4/35） in observation group was lower than control group of 25.71% （9/35）, but there was not statistically significant difference （ P 〉0.05）. Conclusion LA-PDT combined with interferon can effectively treat Bowenoid papulosis is effective and results in low recurrence rate, so it is worthy widely recommended.