蟾蜍类制剂抗乳腺癌的作用及其机制研究进展

蟾蜍类中药传统以内服经全身抗乳腺癌，或外敷以局部治疗晚期乳腺癌，但应用较少。近年研究显示，蟾蜍类中药制剂及单体具有多途径、多靶点抗肿瘤特性，其有效成分能诱导乳腺癌细胞凋亡、抑制细胞增殖及增敏化疗药物实现耐药逆转，有良好的抗乳腺癌效果。本文对蟾蜍类中药制剂和有效单体的抗乳腺癌效果和机制进行综述，蟾蜍类中药制剂和有效单体能通过2种途径诱导乳腺癌细胞凋亡，并针对有效单体蟾毒灵联合化疗药物起到减毒增效及耐药逆转作用提出与介入治疗结合的整合医疗治疗乳腺癌的设想进行讨论，以期为乳腺癌精准治疗提供参考。

Anti-breast cancer effect and mechanism of toad preparations:research progress

As a kind of traditional chinese medicine, Toad is used to treat advanced breast cancer by oral administration or external application, while it is not widely used. Recent studies have shown that toad preparations and monomers have multi-pathway and multi-target anti-tumor properties, and also have good anti-tumor effects on breast cancer. Its effective components can induce breast cancer cell apoptosis, inhibit breast cancer cell proliferation and sensitize chemotherapeutic drugs to reverse drug resistance.By consulting the literature at home and abroad, this paper summarizes the effects of toad preparations and monomer in clinical treatment of breast cancer and the mechanism of anti-breast cancer in basic research. Toad preparations and its effective monomers can induce breast cancer cell apoptosis through 2 ways and we focus on the effect which bufalin can reduce toxicity, enhance efficacy and reverse drug resistance in combination with chemotherapeutic drugs, also we put forward the idea of combination with interventional therapy in the treatment of breast cancer in order to provide reference for further precise treatment of breast cancer.