良性阵发性位置性眩晕患者存在血清25-羟维生素D水平下降

目的 初步探讨血清25-羟维生素D25(OH)D]在良性阵发性位置性眩晕(BPPV)发生、复发中的作用.方法 纳入2013年1月至2014年12月在上海交通大学医学院附属第九人民医院神经内科诊治的部分BPPV患者,根据1年随访结果,分为BPPV未复发组(n=207)及复发组(n=42),并将同期收治的其他眩晕病患者作为对照(n=43),比较3组患者血清25 (OH)D水平的差异,并分析影响所有受试者血清25 (OH)D水平的独立相关因素.结果与眩晕对照组相比,BPPV未复发组、复发组血清25(OH)D水平均下降(P均＜0.01),而复发组与未复发组血清25(OH)D水平差异无统计学意义.BPPV复发组女性比例较其余两组略增高,但差异无统计学意义(P=0.073).所有入组患者中女性血清25(OH)D水平低于男性(18.7±7.5)ng/mL vs (21.7±8.3)ng/mL,P=0.002].多因素逐层线性回归分析显示女性(β=-2.6,P=0.005)、BPPV(β=-5.5,P＜0.001)是患者血清25(OH)D水平的独立影响因素.结论 人血清25(OH)D水平存在性别差异,BPPV患者25(OH)D水平下降.

Serum 25-hydroxyvitamin D is decreased in patients with benign paroxysmal positional vertigo

Objective To explore the role of serum 25-hydroxyvitamin D (25OH]D) in the occurrence and recurrence of benign paroxysmal positional vertigo (BPPV) in patients with BPPV.Methods Patients with nonrecurrent BPPV (n =207) and recurrent BPPV (n =42) were recruited from Department of Neurology of Shanghai Ninth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine from Jan.2013 to Dec.2014,and patients with non-BPPV vertigo diseases in the same period were enrolled as controls (n=43).The recurrence of BPPV was determined within one year of follow-up.The differences of serum 25 (OH)D levels between three groups were compared,and the factors influencing the levels of serum 25 (OH)D of all subjects were analyzed.Results Compared with the control group,serum 25(OH)D levels in the non-recurrent BPPV and recurrent BPPV groups were significantly decreased (both P＜0.01),while there was no significant difference between the non-recurrent BPPV and recurrent BPPV groups.The female proportion was increased in the recurrent BPPV group versus the other two groups,but the difference was not significant (P=0.073).The serum 25 (OH)D level in female patients was significantly lower than that in male patients (18.7±7.5] ng/rnL vs 21.7±8.3] ng/mL,P=0.002).Multiple stepwise linear regression analysis showed that females (β=-2.6,P =0.005) and BPPV (β=-5.5,P＜0.001) were the independent factors influencing the level of serum 25 (OH)D.Conclusion There are gender differences in human serum 25 (OH)D levels,and the level of 25(OH)D is decreased in patients with BPPV.