| 创伤性视神经损伤动物模型研究进展 |
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| 作者姓名： | 林超 董艳 侯立军 |
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| 作者单位： | 第二军医大学长征医院神经外科,上海市神经外科研究所,上海200003 |
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| 摘 要： | 创伤性视神经损伤是在外力作用下引起的视神经损伤，尚缺乏确切的治疗方法，预后较差，是颅脑外伤致残率高的主要原因之一。随着神经生物学和分子生物学研究的进展，视神经损伤和再生的研究成为神经科学研究的热点和难点。本文针对各种创伤性视神经损伤动物模型的优缺点进行综述，为进一步建立理想的动物模型，进行前瞻性实验研究提供理论依据。
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| 关 键 词： | 视神经 损伤 动物模型 |
| 收稿时间： | 9/5/2011 4:16:19 PM |
| 修稿时间： | 2011/11/27 0:00:00 |
Animal models of traumatic optic neuropathy: recent advance |
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| Authors: | LIN Chao DONG Yan and HOU Li-jun |
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| Institution: | Department of Neurosurgery, Changzheng Hospital, Shanghai Neurosurgical Institute, Second Military Medical University, Shanghai200003, China*Corresponding author. |
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| Abstract: | Traumatic optic neuropathy (TON) is caused by blunt trauma and has poor prognosis due to lack of effective treatments, and it is a main reason for high rate of disability after traumatic brain injury. Progression in neurobiology and molecular biology has made it a research focus to study optic nerve damage and regeneration. This article reviews the advantages and disadvantages of various animal TON models, paving a way for establishing ideal TON models and for future prospective researches. |
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| Keywords: | Optic nerve Injury Animal model |
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