巴马小型猪头颈部动脉的磁共振血管成像研究

目的 利用三维时间飞跃法（3D TOF）和时间分辨对比剂动态显像（TRICKS）磁共振血管成像显示巴马小型猪的头颈部血管结构，并比较分析两种技术的动脉成像指标，为大动物脑血管病模型的研究提供参考。方法 应用3.0 T磁共振仪依次对3只健康巴马小型猪行头颈部血管的3D TOF和TRICKS磁共振血管成像，比较两种磁共振血管成像方法的血管清晰度评分，定量分析主要动脉的对比度（CR）、信噪比（SNR）以及对比噪声比（CNR）。结果 在血管清晰度方面，两种方法对巴马小型猪颈总动脉和颈外动脉系显示较好，对后循环的显示欠佳，而3D TOF磁共振血管成像对颅内动脉系的显示优于TRICKS磁共振血管成像（1.60±0.50）分vs（1.37±0.49）分，P=0.019 8]。定量分析发现，TRICKS磁共振血管成像可不同程度提高动脉的CR，但两种方法所得动脉的SNR和CNR差异均无统计学意义（P>0.05）。结论 3D TOF和TRICKS磁共振血管成像均可较好地显示巴马小型猪的颈总动脉及其主要分支结构，并各有优势和局限。

Magnetic resonance angiography for head and neck arteries of Bama minipig

Objective To display the normal vascular structures of head and neck of Bama minipig by three-dimensional time-of-flight (3D TOF) and time-resolved imaging of contrast kinetics (TRICKS) magnetic resonance angiography (MRA), and to compare and analyze the imaging indicators of arteries, so as to provide references for large animal models of cerebrovascular disease. Methods 3D TOF and TRICKS MRA of head and neck vessels in 3 healthy Bama minipigs were performed using a 3.0 T magnetic resonance system. The artery definition scores of the two MRA methods were compared, and the contrast ratio (CR), signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of the main arteries were calculated for quantitative analysis. Results In terms of artery definition, 3D TOF MRA and TRICKS MRA both achieved high scores for the common carotid arteries and external carotid arterial system, but low scores for posterior circulation. 3D TOF MRA was significantly better than TRICKS MRA in displaying the intracranial artery system (1.60±0.50 vs 1.37±0.49, P=0.019 8). Quantitative analysis showed that TRICKS MRA improved CR of arteries to different extents; however, there were no significant differences in SNR or CNR between 3D TOF and TRICKS MRA (P>0.05). Conclusion Both 3D TOF and TRICKS MRA have good and comparable diagnostic performance for common carotid arteries and their main branch structures of Bama minipig, and each method has its advantages and limitations.