| 基于复方抑瘤机制的新型纳米中药胶束剂型设计 |
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| 作者姓名： | 黄若尘 苏永华 苟浩 李威 |
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| 作者单位： | 1. 上海中医药大学研究生院, 上海 201203;2. 海军军医大学(第二军医大学)长海中医医院, 上海 200433;3. 海军军医大学(第二军医大学)纳米医学研究室, 上海 200433*通信作者 |
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| 基金项目： | 国家自然科学基金（8167140246，31470964）. |
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| 摘 要： | 临床实践证明中药复方具有明显的抗肿瘤作用，深入探讨中药复方有效成分的抗肿瘤作用及其对靶细胞的作用机制，对开发新的纳米中药制剂和临床中西医结合治疗肿瘤有着重要意义。本文概述了中药复方的抗肿瘤研究进展及单味中药的抗肿瘤机制，并在此基础上总结分析了目前传统纳米中药剂型的研究进展，然后以中药紫草中的紫草素为例阐述如何根据单味中药的作用机制，利用纳米材料和纳米自组装技术，围绕临床治疗中的难点设计新型纳米高分子中药剂型。
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| 关 键 词： | 抗肿瘤药(中药) 复方 纳米技术 纳米中药胶束剂型 |
| 收稿时间： | 2019/6/26 0:00:00 |
| 修稿时间： | 2019/7/25 0:00:00 |
Design of novel micellar nano-traditional Chinese medicine formulations based on anti-tumor mechanisms of traditional composition |
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| Authors: | HUANG Ruo-chen SU Yong-hu GOU Hao and LI Wei |
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| Institution: | 1. Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;2. Changhai Traditional Chinese Medicine Hospital, Naval Medical University(Second Military Medical University), Shanghai 200433, China;3. Laboratory of Nano Biomedicine, Naval Medical University(Second Military Medical University), Shanghai 200433, China*Corresponding authors |
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| Abstract: | Clinically traditional Chinese medicine (TCM) has been proven to possess obvious anti-tumor effects. It is critical to further explore the effective components and the corresponding mechanism of the TCM against target cells, which also has great significance for developing novel nano-TCM formulations for clinical treatment of tumor. This paper systematically reviews the anti-tumor effects of Chinese herbal compound and the anti-tumor mechanism of single herb. We also summarized the progress in the current traditional nano-TCM preparations. Taking the shikonin in Herba Arnebiae as an example, using the nano-material self-assembly technology, we discussed the design of novel nano-macromolecule TCM formulations while considering the mechanism of single herb and the clinical obstacles. |
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| Keywords: | antineoplastic drugs (TCD) compounds (TCD) nanotechnology micellar nano-formulation of traditional Chinese medicine |
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