高通量血液透析联合超纯析液对维持性血液透析患者贫血的影响

目的:探讨高通量血液透析联合超纯透析液对维持性血液透析(MHD)患者贫血的治疗效果。方法:选取MHD合并肾性贫血患者42例,随机分为观察组和对照组,观察组采用高通量血液透析联合超纯透析液治疗,对照组采用低通量血液透析治疗,比较两组患者治疗后血红蛋白(Hb)、红细胞比容(Hct)、β2-微球蛋白(β2-MG)水平及重组人红细胞生成素(rHuEPO)用量。结果:治疗6月后,观察组Hb、Hct水平明显高于对照组(P<0.05),rHuEPO用量及β2-MG水平显著低于对照组(P<0.05)。结论:高通量血液透析联合超纯透析液可提高患者对EPO的反应性,改善贫血状态。

Effect of high-flux hemodialysis with ultrapure dialysis fluid on treatment of anemia in hemodialysis patients

Objective: To investigate the high-flux hemodialysis with ultrapure dialysis fluid on treatment of anemia in maintenance hemodialysis(MHD) patients.Methods:A total of 42 MHD patients with renal anemia were randomly divided into two groups.Patients in the observation group were treated with-high flux hemodialysis combined with ultrapure dialysis fluid,while the control group treated with low-flux hemodialysis.The levels of hemoglobin(Hb),hematocrit(Hct),rHuEPO dosage and β2-microglobulin(β2-MG) were compared after treatment.Results:After 6 months,levels of Hb and Hct were significantly higher in the observation group than that in the control group(P<0.05),and levels of rHuEPO dosage and β2-MG were significantly lower than that in the control group(P<0.05).Conclusions:Combination therapy of high-flux hemodialysis and ultrapure dialysis fluid for MHD patients with anemia can increase the reactivity of EPO,and improve the renal anemia state.