海南汉族人群AGT基因多态性与冠心病的相关性

目的:探讨AGT基因T174M和M235T多态性与海南汉族冠状动脉性心脏病(CHD)的关系。方法:应用等位基因特异性PCR技术,对334例海南地区汉族CHD患者和193例海南汉族正常对照组中AGT基因T174M、M235T多态位点进行了检测,分析两组基因型频率及等位基因频率。结果:M235T多态位点的等位基因在海南汉族正常对照组和CHD患者组之间存在差异(χ2=4.314,P=0.038);T174M多态位点的基因型在汉族正常对照组和CHD患者组之间也存在差异(P=0.047,Fisher确切概率法)。结论:AGT基因T174M、M235T多态性与海南汉族人群CHD均相关,M235T多态位点235M等位基因是海南汉族人群CHD的易感基因,T174M多态位点174TT和174MM基因型可使海南汉族人群CHD的患病危险性增加。

Correlation between AGT gene polymorphism of Han population and occurrence of coronary heart disease in Hainan province

Objective:To explore the association between AGT gene polymorphism of Han population and occurrence of coronary heart disease(CHD) in Hainan province.Methods:Allele-specific PCR was used to detect the polymorphic of T174M and M235T in 334 patients with CHD and 193 healthy control group,the genotype frequency and alleles were compared between the two groups.Results:There are significant differences in the allele frequency distribution of M235T polymorphism between CHD patients and controls(χ2 =4.314,P=0.038);significant difference in the genotype frequency of T174M polymorphism was also observed between two groups(P=0.047,Fisher’s exact test).Conclusions: The polymorphism of M235T and T174M in AGT gene was significantly correlated with CHD in Han ethnic in Hainan province.Presence of 235M allele of M235T polymorphism was correlated with higher risk of CHD among Han population in Hainan province.174TT and 174MM genotype of polymorphism of T174M in Han population of Hainan province can increase the risk of CHD prevalence.