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参芪扶正注射液对晚期结肠癌临床疗效及免疫功能影响
引用本文:谭光根,刘丽,李静,胡月珍.参芪扶正注射液对晚期结肠癌临床疗效及免疫功能影响[J].海南医学院学报,2013,19(5):627-629.
作者姓名:谭光根  刘丽  李静  胡月珍
作者单位:1. 重庆市第五人民医院肿瘤科,重庆,400000
2. 四川省广元市中心医院肿瘤科,四川广元,628000
基金项目:中国高校医学期刊临床专项资金项目
摘    要:目的:观察晚期结肠癌患者化疗加用参芪扶正注射液治疗后临床疗效和免疫功能变化。方法:40例患者随机分为2组,对照组XELOX化疗方案;而治疗组在化疗方案的基础上,加用参芪扶正注射液治疗,比较治疗前后两组临床疗效、生活治疗、外周血T细胞亚群及NK细胞的水平。结果:治疗组和对照组有效率(CR+PR+NC)分别为85%和65%(P<0.05);治疗组在生活质量的改善上,较对照组有显著性差异(P<0.05);治疗组的外周血T细胞亚群、NK细胞均较治疗前明显增高(P<0.05),而对照组在治疗后T细胞亚群、NK细胞有所下降。结论:参芪扶正注射液联合化疗能提高结肠癌治疗有效率,并显著改善结肠癌患者免疫功能、改善生活质量。

关 键 词:参芪扶正注射液  结肠癌  免疫功能

Effects of Shenqifuzheng injection on immunolologic function of patients with colon cancer
Abstract:Objective:To investigate the effects of Shenqifuzheng injection on immunolologic function of patients with colon cancer.Methods:Forty cases were divided into two groups.Treatment group was treated by Shenqifuzheng injection on the basis of XELOX chemothempy treatment,while control group was treated by XELOX chemotherapy.The therapeutic effect,Karnofsky scores,the blood T-lymphocyte subsets and NK cells were compared after treatment between two groups.Results:The effective rate(CR+PR+NC)was 85%in the treated group and 65%in the control group,showing significant difference between the two groups(P<0.05).The improvement of the quality of life in treatment group were significant different from control group(P<0.05).The values of T-lymphocyte subsets and NK cells from treatment group was significantly higher than that before treatment(P<0.05).Conclusions:Shenqifuzheng injection combined with chemotherapy could not only improve the efficacy of chemotherapy and the quality of life but also regulate immune system.
Keywords:Shenqifuzheng injection  Colon cancer  Immunolologic function
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