乳腺癌90例临床与病理分析

目的:探讨乳腺癌的病理类型与淋巴结转移及雌激素受体(ER)、孕激素受体(PR)、CerbB-2表达的关系。方法:采用SP二步法对90例乳腺癌患者的术后肿瘤石蜡标本进行ER、PR、CerbB-2检测,并与患者的年龄、原发肿瘤病理类型和腋淋巴结转移状况相结合进行分析。结果:ER和PR的表达呈正相关(P<0.05);ER(+)、PR(+)、PR(-)表达率和年龄分布无关(P>0.05);组织病理学类型和ER、PR之间关系差异无统计学意义(P>0.05);无腋淋巴结转移患者的ER(+)、PR(+)表达率显著高于有转移者(P<0.05),ER(-)、PR(-)表达率低于有腋淋巴结转移者(P<0.05)。ER和PR阳性表达率与CerbB-2呈负相关,差异有统计学意义(P<0.05)。结论:乳腺癌患者ER、PR与CerbB-2表达有一定规律,可作为制定综合治疗方案的依据,同时对判断预后有一定意义。

Clinical and pathological analysis of 90 cases with breast cancer

Objective: To explore the relationship between pathological type of breast cancer,lymph nodes metastasis and the expression of estrogen receptor(ER),progesterone receptor(PR) and CerbB-2.Methods: Tested ER,PR,and CerbB-2 in paraffin tumor specimens of 90 patients with breast cancer by S-PR two-step method.Analyzed the relation between the expression of ER,PR and CerbB-2,age,pathological type of breast cancer and lymph nodes metastasis.Results: The expression of ER had positive correlation with PR expression(P<0.05),while the expression of ER & PR had positive correlation with CerbB-2 expression(P<0.05).The expression of ER and PR was independent of age and pathological type of breast cancer(P>0.05),whereas the expressions of ER and PR in patients without axillary lymphatic metastasis were lower than those in positive patients.Conclusion: The expression of ER,PR and CerbB-2 in breast cancer patients is regular to some degree.It can be used as a marker for therapeutic arrangement and prognostic judement.