多发性硬化的影像学特征及与生活质量相关性分析

目的:利用1.5T磁共振成像(MRI)对某地区2005年～2009年170例多发性硬化(MS)患者进行检查,了解该地区多发性硬化的影像学特点,并对不同病损部位的多发性硬化患者与生活质量进行相关性分析。方法:应用超导型1.5TMRI对所有病例均行SE序列T1WI、T2WI扫描,同时采用多发性硬化生活质量量表(MSQOL-54)、Kurtzk残疾状态调查量表(EDSS)对患者进行调查研究。结果:单纯脑部损害MS患者85例,单纯脊髓损害MS患者46例,脑脊髓混合损害MS患者39例。单纯脊髓损害患者EDSS、躯体生活质量S1和精神生活质量S2评分分别是(4.13±2.37)、(53.55±23.34)和(51.95±51.95);单纯脑部损害患者评分分别为(2.52±1.90)、(62.45±23.76)和(62.48±18.60);脑脊髓混合损害患者评分分别为(3.21±1.57)、(50.70±20.61)和(46.23±15.33)。结论:MRI有助于早期发现MS患者的临床病灶;对单纯脊髓损害MS患者生活质量影响最大。

Imaging features of multiple sclerosis and its correlation with patients’ life quality

Objective： To analyze imaging features of 170 patients with multiple sclerosis under 1. 5T MRI and its correlation with patients＇ life quality. Methods： A total of 170 patients enrolled during 2005 and 2009 underwent 1.5T MRI detection for TlWI and T2WI of SE sequence images, questionnaires of multiple sclerosis quality of life （MSQOL-54）, and Kurtzk Disability Status Questionnaire （EDSS） were applied to evaluate patients life quality. Results： Simple brain damage was shown in 85 cases; simple spinal cord injury in 46 patients, the combination of the two was presented in 39 cases. EDSS, physical life quality （S1） and mental life quality （S2） of the three categories of patients were 4. 13.53.55and 51.95, vs. 2.52.62.45and62. 48 vs. 3.21.50.70and 46.23. Conclusions： MRI can help to detect lesions in patients with multiple sclerosis; besides, life quality of multiple sclerosis patients with simple spinal cord injury is the most affected by the disease.