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生长抑素与食管癌
引用本文:杨洋.生长抑素与食管癌[J].海南医学院学报,2008,14(2):137-139.
作者姓名:杨洋
作者单位:天津市第五中心医院胸外科,天津,300021
摘    要:目的:检测食管癌组织中生长抑素(somatostatin,SS)的表达情况,研究这种生物因子与临床常见指标间的联系,试评价其在食管癌预后及生物治疗中的价值。方法:运用免疫组织化学SP法对99例经手术治疗的食管癌患者的石蜡组织标本进行研究。结果:SS与组织分化程度和形态学分型显著相关。分化越差,SS的表达越低。SS与总生存期(OS)有显著相关性。SS可以作为影响OS的独立预后因子。取值越低,生存期越短。结论:SS在食道癌的形成、发展过程中占有一定的地位。SS可能是一种判断食管癌预后的独立因子。

关 键 词:食管肿瘤  生长抑素  免疫酶技术
文章编号:1007-1237(2008)02-0137-03
修稿时间:2007年12月13

Study on somatostatin and esophageal carcinoma
YANG Yang.Study on somatostatin and esophageal carcinoma[J].Journal of Hainan Medical College,2008,14(2):137-139.
Authors:YANG Yang
Abstract:Objective: To determine the expression of somatostatin(SS) in esophageal carcinoma and analyze its relations to the common clinical indicators,evaluate its value for the biological therapy and prognosis of esophageal carcinoma.Methods: Waxed tissue samples of 99 patients with surgery confirmed esophageal carcinoma were studied using SP method of immunohistochemistry.Results: SS correlated significantly with the cell differentiation and morphological types.The less differentiated the cell,the lower the SS expressed.SS correlated significantly with the overall survive(OS) time.SS might serve as an independent factor of prognosis for the evaluation of OS.The lower the value,the shorter the survive time.Conclusion: SS plays a certain role in the generation and progress of the esophageal carcinoma.SS may be an independent factor for the prognostic evaluation of the esophageal carcinoma.
Keywords:Esophageal tumors  Somatostatin(SS)  Immunoenzyme technique
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