急性冠脉综合征患者血清hs-CRP、cTnI、BNP及D-二聚体水平变化

目的：探讨急性冠脉综合征（acute coronary syndrome，ACS）患者血清超敏C反应蛋白（hs—CRP）、心脏肌钙蛋白I（cTnI）、脑钠尿肽（BNP）及D-二聚体的水平变化。方法：选择我院收治的90例ACS患者，分为不稳定型心绞痛患者（UAP）组52例，急性心肌梗死（AMI）组38例，选取稳定型心绞痛（SAP）患者45例及45例健康者设为对照组，比较各组血清hs—cRP、BNP及D-二聚体水平。结果：（1）AMI组与UAP组血清hs—CRP、cTnI、BNP及D-二聚体明显高于SAP组及对照组，AMI组高于UAP组，SAP组高于健康对照组，差异均具有统计学意义（P〈0．05）；（2）ACS组hs—CRP和cTnI的呈显著性正相关（P〈0．05）；（3）经过6个月的随访，发现有18例患者发生MACE，MACE组患者血清hs—CRP水平明显高于无MACE组，差别有统计学意义（P〈0．05）。结论：血清hs—CRP、cTnI、BNP及D-二聚体水平均与ACS患者的冠脉病变程度密切相关。

Changes of serum hs-CRP,cTnl, BNP and D-dimer levels in patients with acute coronary syndrome

Objective. To investigate changes of serum hs-CRP, cTnI, BNP and D-dimer levels in patients with acute coronary syndrome. Methods. Totally 90 ACS patients in our hospital were divided into UAP group （52 cases） and AMI group （38 cases）. Besides, selected 45 patients with stable angina pectoris （SAP） and 45 healthy people as the control group, the levels of serum hs-CRP, cTnI, BNP and D-dimer were compared. Results. 1. The serum hs-CRP, cTnI, BNP and D-dimer in AMI group and UAP group was significantly higher than the SAP group and control group （P〈0.05）, and these indicator levels in the AMI group were higher than the UAP group （P〈0.05）, higher in SAP group than in the healthy control group （P〈0.05） ; 2. The serum hs-CRP and cTnI in ACS patients were positively correlated （P〈0. 05） 3. According to 6 months of follow-up, 18 patients developed MACE, the levels of serum hs-CRP levels in MACE group was significantly higher than those with no-MACE group （P〈0.05）. Conclusion. Serum hs- CRP, cTnI, BNP and D-dimer levels are closely related with the severity of coronary artery disease in ACS patients.