伽马刀联合薄芝糖肽注射液治疗局部晚期肺癌疗效观察

【目的】研究伽马刀联合薄芝糖肽注射液治疗局部晚期肺癌的近期临床疗效。【方法】采用SGS-I型立体定向伽马射线全身、系统治疗84例晚期肺癌患者,其中联合薄芝糖肽注射液治疗42例。伽马刀治疗的剂量为50%～65%等剂量曲线包绕靶区95%以上,治疗总剂量为35～45 Gy;治疗8～12次,患者通常1次/d。联合药物组从伽马刀治疗前3 d给予输注薄芝糖肽注射液,6 ml/d,共3周。【结果】伽马刀治疗后联合组患者在WBC、Karnofsky评分、视觉模拟评分法(Visual Analogue Scale/score,VAS法)评定疼痛标准、世界卫生组织(World Health Organization,WHO)实体瘤疗效评定标准及临床不良反应等指标上与对照组患者比较,两组比较差异具有统计学意义(P<0.05);伽马刀治疗后联合组患者在(carcino-embryonic antigen,CEA)指标上与对照组患者比较两组差异无统计学意义(P>0.05)。联合治疗组疗效评估较优于对照组,差异具有统计学意义(P<0.05)。不良反应中联合组白细胞下降、胸水增加、呼吸道反应发生率,与对照组比较,两组差异均有统计学意义(P<0.05)。【结论】伽马刀治疗局部晚期肺癌效果较好,近期疗效确切,联合薄芝糖肽注射液后可使其不良反应减轻,且有增强伽马刀疗效的作用,可以作为临床放疗的辅助药物。

Bozhi Glycopeptide injections combined with Gamma Knife to treat locally advanced lung cancer

【Objective】 To investigate clinical effects of Gamma Knife treatment combined with Bozhi Glycopeptide injections on locally advanced lung cancer.【Methods】 84 patients with advanced lung cancer were treated with the SGS-I gamma ray,with was combined with Ganoderma capense（Lloyd）Teng injections to treat 42 of them.Gamma Knife treatment used the 50%~60% does isodose curve,covering more than 95% of the larger area,with a single peripheral dose of 3~4 Gy for tumor≤5 cm,2.5～3.5 Gy for the tumor〉5 cm.The total dose was 35~45 Gy,with 8~12 times of treatment and once a day.For the joint treatment group（Gamma Knife plus Bozhi Glycopeptide injections）,radiosurgery Bozhi Glycopeptide injection was applied to each patient three days before Gamma Knife treatment,with 6 ml/d for three weeks.【Results】 After treatment,WBC,Karnofsky score,VAS method to assess pain standard,WHO solid tumor evaluation of curative effect and clinical effect in joint group were distinctly better than control group（P 〈 0.05）.After treatment,CEA in joint group were no significant with control group（P 〉 0.05）.【Conclusion】 Effective treatment with the Gamma Knife was observed on locally advanced lung cancer use of Bozhi Glycopeptide injections can attenuate pain reactions,enhance the effect of treatment,and serve as an adjuvant drug for clinical radiotherapy.