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水溶性硫硒化镉量子点纳米颗粒对小鼠皮肤渗透性的影响
引用本文:唐蕾,宋光明,曹瑾,张春玲.水溶性硫硒化镉量子点纳米颗粒对小鼠皮肤渗透性的影响[J].武警医学院学报,2014(5):369-372,F0002.
作者姓名:唐蕾  宋光明  曹瑾  张春玲
作者单位:[1]武警后勤学院电子电工教研室,天津300309 [2]武警后勤学院药理学教研室,天津300309 [3]武警后勤学院数学教研室,天津300309 [4]南开大学物理科学学院,天津300071
基金项目:武警后勤学院重点项目(WYZ201003) 致谢 感谢天津泰达医院电镜室董亚利主任在TEM检测上的帮助.
摘    要:目的]研究水溶性硫硒化镉(CdSeS)量子点纳米颗粒对小鼠皮肤渗透性的影响。方法]在雄性ICR鼠背部脱毛部位涂抹直径约为5nm,发光波长为620nm的量子点O.32nmol,利用荧光显微镜和透射电镜对施药皮肤部位显微观察皮肤渗透性。结果]荧光显微像显示量子点能够堆积在皮肤的表皮层中和真皮层的毛囊和腺体中,透射电镜显示量子点附着在皮肤表面和吸附在角质细胞的两侧。结论]量子点纳米颗粒对小鼠皮肤具有一定渗透性,而且随着施加量子点溶液时间加长,渗透量略有增加,但是主要聚集在皮肤表面和角质层细胞的两侧。

关 键 词:量子点  纳米颗粒  透皮吸收  荧光显微镜  透射电镜

Study the transdermal delivery capacity of water-soluble CdSeS quantum dots nanoparticles through mouse skin
TANG Lei,SONG Guang-ming,CAO Jin,ZHANG Chun-ling.Study the transdermal delivery capacity of water-soluble CdSeS quantum dots nanoparticles through mouse skin[J].Acta Academiae Medicinae CPAPF,2014(5):369-372,F0002.
Authors:TANG Lei  SONG Guang-ming  CAO Jin  ZHANG Chun-ling
Institution:(Electronic and Electric Engineering Section of Logistics University of PAPF, Tianjin 300309, China)
Abstract: Objective ] To study the transdermal delivery capacity of water-soluble CdSeS quantum dots (QDs) nanoparticles through mouse skin. Methods ] QDs solution (0.32 nmol) was coated on the dorsal hairless skin of male ICR mice. Fluorescence microscope and transmission electron microscope(TEM) were used to observe the distribution of QDs in the skin. Results ] The fluorescence mi- croscopy images show that QDs could deposite on the skin, the epidermis and dermis layers of the hair follicles and glands, and TEM further demonstrated that quantum dots were attached to the skin surface and adsorbed on both sides of stratum corneum layers. Conclusion ] QDs had permeability on mouse skin and penetration increased slightly with time. Most of the QDs deposite on the skin surface, some QDs could penetrate into the dermal layer and were limited to the uppermost stratum corneum layers and the hair follicles.
Keywords:Quantum dots  Nanoparticle  Transdermal delivery  Fluorescence microscopy  Transmission electron microscopy
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