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苯甲酸类化合物对磷酸川芎嗪微乳透皮速率的影响
引用本文:崔颖,王鹏,郭鹏,嵇辉.苯甲酸类化合物对磷酸川芎嗪微乳透皮速率的影响[J].武警医学院学报,2013(11):982-984.
作者姓名:崔颖  王鹏  郭鹏  嵇辉
作者单位:[1]武警后勤学院药物化学教研室,天津300309 [2]武警后勤学院解剖学教研室,天津300309 [3]天津市职业与环境危害防治重点实验室,天津300309 [4]武警总医院放射科,北京100000
摘    要:【目的】研究苯甲酸类离子对试剂对磷酸川芎嗪微乳体外透皮性质的影响。【方法】通过恒温振荡法和赢式Franz扩散池法考察不同苯甲酸类离子对试剂对磷酸川芎嗪表观分配系数及微乳体外渗透曲线影响。【结果】苯甲酸类化合物均能增加磷酸川芎嗪的表观油水分配系数,其中苯甲酸和对硝基苯甲酸能够显著提高其微乳的透皮速率,且随着用量的增加,对硝荩苯甲酸对磷酸川芎嗪的促渗作用增加。【结论】苯甲酸类化合物能够通过形成离子对增加磷酸川芎嗪微乳的透皮吸收速率。

关 键 词:磷酸川芎嗪  徽乳  苯甲酸化合物  离子对  透皮速率

Effect of compounds with structure of benzoic acid on transdermal flux of ligustrazing phosphate microemulsion
CUI ying,WANG peng,GUO peng,JI hui.Effect of compounds with structure of benzoic acid on transdermal flux of ligustrazing phosphate microemulsion[J].Acta Academiae Medicinae CPAPF,2013(11):982-984.
Authors:CUI ying  WANG peng  GUO peng  JI hui
Institution:(Department of Medicine Chemistry, Logistics University of Chinese People's Armed Police Forces, Tianjin 300309, China)
Abstract: Objective ]To study the effect of ion pair regents with structure of benzoic acid on transdermal flux of l igustrazine phosphate in vitro. Method] The effects of ion pair reagent on apparent partition coefficient of ligustrazine phosphate and transdermal curve of microemulsion, were investigated with oscillation method at constant temperature and FRANZ diffusion method. Result]The ion pair regents with structure of benzoic acid increased apparent partition coefficient of ligustrazine phosphate, benzoic acid and nitro benzoic acid improved transdermal flux of ligustrazine phosphate in microemulsion significantly, and the transdermal enhancement effect of the latter were increased with the amount ratio increase between the ion pair regent and ligustrazine phosphate. Conclusion] Compounds with benzoic acid could increase transdermal flux of ligustrazine phosphate microemulsion through formation of ion pair.
Keywords:Ligustrazine phosphate  Microemusion  Benzoic acid  Ion pair  Transdermal flux
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