| 急性缺血性卒中血小板α颗粒和血浆TXB2含量的变化观察 |
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| 引用本文： | 邓本强,周勇.急性缺血性卒中血小板α颗粒和血浆TXB2含量的变化观察[J].上海医学,1993,16(9):501-503. |
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| 作者姓名： | 邓本强 周勇 |
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| 作者单位： | 第二军医大学附属长海医院神经科，第二军医大学附属长海医院神经科，第二军医大学附属长海医院实验诊断科，第二军医大学附属长海医院实验诊断科 |
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| 摘 要： |
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| 关 键 词： | 血小板 α颗粒 中风 血栓烷 |
OBSERVATIONS ON THE CHANGE OF PLATELET ALPHA GRANULE AND PLASMA TXB_2 LEVEL IN AGUTE ISGHEMIC STROKE |
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| Deng Ben-qiang et al.OBSERVATIONS ON THE CHANGE OF PLATELET ALPHA GRANULE AND PLASMA TXB_2 LEVEL IN AGUTE ISGHEMIC STROKE[J].Shanghai Medical Journal,1993,16(9):501-503. |
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| Authors: | Deng Ben-qiang |
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| Institution: | Deng Ben-qiang et al Department of Neurology,Changhai Hospital,the Second Military Medical University,Shanghai 200433 |
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| Abstract: | We used transmission electron microscopy to count the alpha granules containedwithin platelets and serial radio-immunoassay was used to determine the plasma TXB_2level from 14 acute ischemic stroke patients and 15 healthy controls.Compared withthose from controls,platelets from stroke patients contained significantly fewer alphagranules(p<0.001) and platelet area showed no change(p>0.05),The results showedthat the excretion of TXB_2 in patients was obviously higher than that in normal con-trols(p<0.01),the more severe the clinical course,the lower the patient's alpha gra-nules(p<0.01).These observations support the prssence of increased platelet secretionassociated with acute ischemic stroke and raise the possibility that platelet secretionmay be an important difference to the mechanical occlusion of blood vessels by plateletaggregates in the pathogenesis of cerebral infarction. |
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| Keywords: | Acute ischmic stroke Platelet alpha granule TXB_2 |
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