| 胰岛素样生长因子与炎症性肠病活动度和病变范围的相关性 |
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| 引用本文： | 王俊珊,刘占举,郑萍,王兴鹏.胰岛素样生长因子与炎症性肠病活动度和病变范围的相关性[J].上海医学,2010,33(1). |
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| 作者姓名： | 王俊珊 刘占举 郑萍 王兴鹏 |
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| 作者单位： | 1. 同济大学附属第十人民医院消化内科,同济大学消化系疾病临床医学中心,上海,200072
2. 上海交通大学附属第一人民医院消化科 |
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| 摘 要： | 目的 通过检测炎症性肠病(IBD)患者血清胰岛素样生长因子(IGF-1)水平以及肠道黏膜组织中IGF-1的表达,探讨IGF-1与IBD活动度和病变部位之间关系.方法 收集2008年1月-10月诊断为IBD的患者75例,其中克罗恩病(CD)30例,溃疡性结肠炎(UC)45例,收集同期行结肠镜检查未见异常且年龄、性别构成与IBD组相近的39例患者作为对照组.根据Harvey和Bradshow标准的疾病活动指数(简化CDAI)及Southerland疾病活动指数(UCAI)对CD和UC患者的疾病程度进行分级.测定所有患者的血清IGF-1水平以及肠道黏膜组织的IGF-1表达.结果 活动期UC和CD患者的血清IGF-1水平分别为(149.37±101.81)、(112.23±45.94)ng/mL;缓解期分别为(159.4±91.63)、(142.89±121.61)ng/mL,均显著低于对照组的(236.00±62.55)ng/mL(P值均0.05).UC组中,全结肠型和部分结肠型患者的血清IGF-1水平分别为(157.56±96.60)、(140.47±101.68)ng/mL,两亚组间的差异无统计学意义(P>0.05).CD组中,结肠累及型和小肠型患者的血清IGF-1水平分别为(97.48±29.35)、(145.90±113.14)ng/mL,两亚组间的差异无统计学意义(P>0.05).IBD组患者的肠道黏膜IGF-1呈高表达,而对照组呈低表达.结论 血清IGF-1对判断IBD的活动度、病变部位的特异性不强.IBD患者的肠壁组织中可见IGF-1蛋白表达显著增强,可能肠间质细胞局部分泌的IGF-1介导了炎症的发生、发展.
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| 关 键 词： | 炎症性肠病 溃疡性结肠炎 克罗恩病 胰岛素样生长因子 |
Correlation analysis of insulin-like growth factor-1 with activity or involvement of inflammatory bowel diseases |
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| WANG Junshan,LIU Zhanju,ZHENG Ping.Clinical Center of Gastroenterology,Shanghai Tenth People\'s Hospital,Tongji University,Shanghai ,China.Correlation analysis of insulin-like growth factor-1 with activity or involvement of inflammatory bowel diseases[J].Shanghai Medical Journal,2010,33(1). |
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| Authors: | WANG Junshan LIU Zhanju ZHENG PingClinical Center of Gastroenterology Shanghai Tenth People\'s Hospital Tongji University Shanghai China |
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| Institution: | WANG Junshan,LIU Zhanju,ZHENG Ping.Clinical Center of Gastroenterology,Shanghai Tenth People\'s Hospital,Tongji University,Shanghai 200072,China |
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| Abstract: | Objective To explore the serum level of insulin-like growth factor-1(IGF-1) and IGF-1 expression in intestinal mucosa of patients with inflammatory bowel disease(IBD),and to investigate the relationship between IGF-1 and the activity and involvement area of IBD.Methods Seventy-five IBD patients,45 with ulcerous colitis(UC) and 30 with Crohn disease(CD),who were treated during Jan.2008 to Dec.2008,were included in the present study.The patients were classified according to Bradshow Classification(CDAI) and S... |
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| Keywords: | Inflammatory bowel disease Ulcerative Colitis Crohn's Disease Insulin-like growth factor-1 |
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