平喘中药对致敏性哮喘豚鼠气道的作用

为研究平喘中药对气道的作用，我们测得致敏性哮喘豚鼠支气灌洗液（ＢＡＬＦ）白蛋白，细胞总数及嗜酸性粒细胞数均比正常对照组豚鼠明显增多（Ｐ〈０．０１），淋巴毒素Ｃ４（ＬＴＣ４）及Ｅ４（ＬＴＥ４）比对照组增高（Ｐ〈０．０５），致敏豚鼠在吸入过敏原促发哮喘前腹腔注入平喘中药（麻黄，百部，地龙，杏仁和防风）而哮喘时ＢＡＬＦ的白蛋白，细胞总数及嗜酸性粒细胞比未用中药的哮喘组明显下降（Ｐ〈０．０１），ＬＴＣ４和

The Effect of Traditional Chinese Medicine on Airway in Asthmatic Guinea Pig

In order to investigate the effect of traditional Chinese medicine on airway,we measuredbronchoalvealar lavage fluid(BALF)of asthmatic guinea pigs before and after in jecting tra-ditional Chinese medicine in the abdomen cavity during the episode of asthma. The resultsrevealed that the total number of cells and number of eosin ophils in BALF were increased af-ter exposure to allergen in sensitized guinea pigs compared to those in control animals(P<0.01).The level of albumin in BALF of sensitized guinea pigs was higher than those of con-trol animals(P<0.01).Levels of leukotrienes C_4 and E_4 were higher than those of controlanimals(P<0.05). After injected with the medieines(including Lumbricus, Radix Stemonae,Semen Arme-niacae Amarum,Herba Ephedra and radix Ledebouriellae),indices of cell were decreased(P<0.01),level of albumin(P<0.01),Leutrienes C_4 and E_4 were lower than the group with-out injection(P<0.05).These results suggested that the traditional Chinese medicine couldinhibit airway eosinophilia, diminish the epithelial damage and effusion of Albumin,The ex-periment showed that the traditional Chinese medicine have important protective effect on theairway in episodes of asthma.