深圳市宫颈门诊就诊者高危型人乳头瘤病毒和生殖道沙眼衣原体感染情况

目的分析深圳地区宫颈门诊就诊者高危型人乳头瘤病毒(high-risk human papillomavirus,HR-HPV)和生殖道沙眼衣原体(genital chlamydia trachomatis,GCT)感染情况及其与子宫颈癌/癌前病变的关联。方法回顾性地收集2018年1—12月深圳市妇幼保健院妇科宫颈门诊就诊者病历资料,采用非条件Logistic回归分析高危型HPV和GCT与子宫颈病变的关联,计算比值比(odds ratio,OR)和95%置信区间(confidence interval,CI)。结果本研究纳入深圳市宫颈门诊就诊者881例,平均年龄(36.86±9.46)岁。高危型HPV阳性率为71.7%,GCT的阳性率为7.4%,高危型HPV合并GCT的感染率为5.6%。高危型HPV阳性率随年龄递增(P趋势=0.001),而GCT阳性率和高危型HPV合并GCT感染率呈现随年龄逐渐下降的趋势(趋势性P=0.002和0.014)。多因素Logistic回归分析显示,高危型HPV感染与细胞学ASCUS+及病理学CIN1+存在显著关联,OR值及95%CI分别为3.72(2.35,5.90)和6.90(3.79,12.57);未发现GCT感染或高危型HPV合并GCT感染与细胞学ASCUS+及病理学CIN1+存在关联。结论宫颈门诊就诊者是深圳市高危型HPV和GCT感染的重点人群,需有针对性地做好健康教育、安全套促进和常规筛查工作。

High-risk HPV and genital Chlamydia trachomatis infections among outpatients at a central clinic in Shenzhen

Objective The Objective of this study is to detect the infection rates of high-risk human papillomavirus (HR-HPV) and genital Chlamydia trachomatis (GCT) among outpatients at a cervical clinic in Shenzhen, as well as to explore the associations between these infections and cervical cancer or precancer lesions.Methods Medical records of the outpatients at cervical clinic in Shenzhen Maternity and Child Healthcare Hospital throughout 2018 were retrospectively collected, and the association between HR-HPV and GCT and cervical lesions was analyzed using non-conditional Logistic regression to calculate odds ratio (OR) and 95% confidence interval (CI).Results In total, 881 cases were included in analysis with a mean age of (36.86±9.46) years. The infection rates of HR-HPV, GCT, and co-infection of GCT and HR-HPV was 71.7%, 7.4%, and 5.6%, respectively. HR-HPV infection increased with age (P for trend=0.001), while GCT infection and GCT co-infection with HR-HPV decreased with age (P_trend=0.002 and 0.014). Multivariate Logistic regression analyses showed that HR-HPV was positively associated with cervical lesions, including both cytology with ASCUS+ and histopathology CIN1+, and the ORs and 95%CIs were 3.72 (2.35, 5.90) and 6.90 (3.79, 12.57). However, we did not observe positive associations of GCT or co-infection of GCT and HR-HPV with cervical lesions.Conclusion Outpatients at cervical clinics are the key population at risk of HR-HPV and GCT infections in Shenzhen area. Targeted interventions, such as health education, condom use promotion, and routine screening, should be placed on these women.