371株深部感染真菌的菌群分布及药物敏感性分析

目的:了解中山大学附属第一医院检出深部感染真菌的菌群分布及药物敏感性状况，为临床治疗提供参考依据。方法:所分离出的真菌用API 20CAUX鉴定，用ATB FUNGUS进行药敏实验。结果:371株真菌中白色念珠菌228株、热带念珠菌73株、光滑念珠菌38株、近平滑念珠菌12株、无名酵母菌6株、新型隐球菌3株、平常念珠菌3株、季也蒙念珠菌2株。371株真菌对5-氟胞嘧啶、两性霉素B、制菌霉素、咪康唑、益康唑、酮康唑总的敏感率分别为92％、97％、96％、57％、63％、69％。结论:深部真菌感染主要由白色念珠菌、热带念珠菌、光滑念珠菌引起。对两性霉素B、制菌霉素、5-氟胞嘧啶的敏感性最高，保持了较高的抗菌活性，这三种抗菌药仍然是治疗深部真菌感染的有效药物。

Analysis of the distribution and drug susceptibility of 371 fungi strains resulting in deep infections

Objective To investigate the distribution and drug resistance situation of the fungi which caused deep part infection. Methods The isolated fungi were indentified with API 20C AUX and drug susceptibility tests was conducted by using ATB FUNGUS. Results 228 strains of Candida albicans, 73 strains of Candida tropicalis, 38 strains of Candida glabrata, 12 strains of Candida papasilosis, 6 strains of Candida famata, 3 strains of Cryptococcus neofermans, 3 strains of Candida inconspicua, 2 strains of Candida guilliermondii were isolated. The total sensitivity of 371 strains of fungi to 5-fluorocytosine, amphotericin B, mycomycin, miconazole, econazole, ketoconazole were 92%,97%,96%,57%,63%,69%,respectively. Conclusion The dominant pathogenic fungi which caused deep part infection were Candida albicans, Candida tropicalis and Candida glabrata. Amphotericin B, mycomycin and 5-fluorocytosine were most sensitive to the pathogenic fungi and remain to be the most effective drug to cure deep part infection.