延安地区HBV基因型与干扰素抗病毒治疗效果分析

目的研究延安地区不同HBV基因型临床特征及其干扰素抗病毒治疗的疗效。方法用PCR的方法鉴定延安地区130例慢性乙型肝炎患者的HBV基因型,并对患者应用α-2b干扰素抗病毒治疗12个月,随访12个月,对治疗及随访资料进行回顾性研究。结果 （1）在延安地区130例慢性乙型肝炎患者中,C基因型98例、15例为B基因型,可见延安地区HBV基因型以B、C基因型为最常见的基因型;（2）B、C、B＋C基因型HBeAg阳性率分别为66.7%、82.7%、54.5%,可见B基因型HBeAg阳性率明显低于C基因型,且B＋C基因型HBeAg阳性率也明显低于C基因型;（3）B基因型与B＋C基因型、B基因型与D基因型、C基因型与D基因型、D基因型与B＋C基因型在HBeAg阳性率方面均无显著性差异;（4）B基因型对干扰素的完全应答率、持续应答率明显高于C基因型,而无应答率低于C基因型;（5）B＋C基因型的干扰素应答率低于B、C基因型。结论延安地区B、B＋C基因型HBeAg阳性率明显低于C基因型;B基因型对干扰素的完全应答率高于C基因型,B＋C基因型的干扰素应答率低于B、C基因,提示HBV基因型对优化慢性乙型肝炎抗病毒治疗方案有临床价值。

The research on relationship between HBV genotypes and interferon antiviral treatment in Yan'an region

Objective To explore the clinical features and efficacy of antiviral theray of HBV genotypes in Yan'an region.Method HBV genotypes were identified in 130 chronic hepatitis B patients by PCR method,.and they had been treated with interferon alpha-2b antiviral therapy for 12 months,followed up for 12 months,then the data on treatment and follow-up were studied retrospectively.Result Most :1 There are130 B patients of chronic hepatitis B in in Yan'an region,98 cases of C genotype,15 cases were B genotype,it co...