IGF1和IGF2在胃肠道间质瘤中的表达

目的研究IGF1、IGF2在胃肠道间质瘤（GISTs）组织中的表达与临床病理学特征的关系及其相互间的相关性。方法应用免疫组化SABC法检测55例胃肠道间质瘤中IGF1和IGF2的表达情况，结合临床病理学资料（性别、组织学分型、肿瘤直径、组织学分级及部位）分组比较并进行统计学分析。结果55例GISTs中IGF1和IGF2的阳性表达率分别为61．8％（34／55）和49．1％（28／55）。不同肿瘤直径及组织学分级之间IGF1和IGF2的阳性率有显著性差异（P〈0．05），但与性别、组织学分型、部位、肿瘤结节数、原发／复发之间无关（P〉0．05）。结论IGF在GISTs的发生和增殖中发挥作用，可能为GISTs良恶性的判断提供依据。

The expression of insulin-like growth factor I and Insulin - like growth factor II in gastrointestinal stromal tumors and their clinicopathologic significance

Objective To investigate the expression of insulin - like growth factor I （IGF I） and insulin - like growth factor Ⅱ（ IGF Ⅱ） and their clinicopathologic significance in the proliferation of gastrointestinal stromal tumors （ GISTs）, and the correlation between IGF1 and IGFR2. Methods Immunohistochemical method SABC was used to detect the expression of IGF1 and IGF2 in 55 GISTs cases. The correaltion of the positive rate with clinicopathologic factors including sex, histological subtype, tumor size, histological grade and localization was analysed. Results Of 55 GISTs cases, 34 cases were found positive for IGF1 （61.8%） and 27 cases positive for IGF2 （49.1%）. Significant difference in the positive rate of IGF1 or IGF2 was observed among different tumor size or histological grade groups （P 〈 0.05 ）. The expression was not correlated with the factors of sex, histological subtype, localization, tumor node number, original/recurrence in different groups （P 〉 0. 05）. Conclusion IGF1 and IGF2 play certain roles in pathogenesis and proliferation of GISTs, which may be used as an objective index for distinguishing malignant GISTs from benign ones.