| 轮叶党参总皂甙对环磷酰胺诱发的小鼠骨髓细胞微核的拮抗作用 |
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| 引用本文： | 韩龙哲,韩春姬,叶萌,崔香淑.轮叶党参总皂甙对环磷酰胺诱发的小鼠骨髓细胞微核的拮抗作用[J].延边医学院学报,2003,26(1):9-11. |
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| 作者姓名： | 韩龙哲 韩春姬 叶萌 崔香淑 |
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| 作者单位： | [1]延边大学医学院卫生学教研室，吉林，延吉133000 [2]延边大学医学院成人教育部，吉林，延吉133000 |
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| 摘 要： | 目的 ]探讨轮叶党参总皂甙对环磷酰胺诱发的小鼠骨髓细胞微核的拮抗作用 .方法 ]进行小鼠骨髓嗜多染红细胞微核实验 .结果 ]腹腔注射环磷酰胺可诱发的小鼠骨髓嗜多染红细胞微核率明显增加 ,经口灌胃轮叶党参总皂甙的同时腹腔注射环磷酰胺 ,可使微核率显著下降 .结论 ]轮叶党参总皂甙对环磷酰胺诱发的小鼠骨髓嗜多染红细胞微核有拮抗作用
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| 关 键 词： | 微核 植物 药用 皂苷类 环磷酰胺 小鼠 |
| 文章编号： | 1000-1824(2003)01-0009-03 |
Inhibitory effects of the Codonopsis Lanceolata saponins on micronuclei of bone marrow induced by cyclophosphamide in mice |
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| HAN Long zhe ,HAN Chun ji ,YE Meng ,CUI Xiang shu.Inhibitory effects of the Codonopsis Lanceolata saponins on micronuclei of bone marrow induced by cyclophosphamide in mice[J].Journal of Medical Science Yanbian University,2003,26(1):9-11. |
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| Authors: | HAN Long zhe HAN Chun ji YE Meng CUI Xiang shu |
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| Institution: | HAN Long zhe 1,HAN Chun ji 1,YE Meng 1,CUI Xiang shu 2 |
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| Abstract: | OBJECTIVETo study the inhibitory effects of the Codonopsis Lanceolata saponins on polychromatic erythrocytes with micronucleus induced by cyclophosphamide (CP) in mice.?METHODS?To use micronucleus test in polychromatic erythrocytes of mice bone marrow.?RESULTS?The intra abdominal CP injection could induce the marked increase of rate of polychromatic erthrocytes with micronuclei(MPCE) in mice, but when various doses of the Codonopsis Lanceolata saponins were given simultaneously, the rate of MPCE significantly decreased in all Codonopsis Lanceolata saponins groups.?CONCLUSION?The Codonopsis Lanceolata saponins could inhibit the MPCE induced by CP in mice. |
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| Keywords: | micronuclei plants medicinal saponins cyclophosphamide mice |
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