小鼠急性中毒性肝炎时血清结合胆酸含量与谷丙转氨酶活性的比较

应用放射免疫分析法定测定被不同剂量四氯化碳染毒的小鼠血清结合胆酸的含量,并与血清谷丙转氨酶活性进行比较,探讨了这两项指标的关系。实验结果表明,血清结合胆酸含量在10mg/kg体重四氯化碳染毒组显著高于对照组(p<0.05),而血清谷丙转氨酶活性则在20mg/kg体重四氯化碳染毒组显著高于对照组(p<0.01)。可以认为,就诊断中毒性肝炎而言,检测血清结合胆酸的含量较检测血清谷丙转氨酶活性更为敏感。

A Comparison of Concentration of Serum Conjugated Bile Acid and Activity of Serum Glutamic Pyruvic Aminotransferase in Toxic Hepatitis in Mice

The concentraton of serum conjugated bile acids measured by radioimmunoassay in toxic hepatitis induced by carbon tetrachloride(CCl_4)in mice,was compared with the activity of serum glutamic pyruvic aminotansferase(SGPT).The results show that the concentration of serum conugated bile acids was increased in 10mg/kg CCl_4-exposed group significantly(P<0.05)and the activity of SGPT was markedly increased in 20mg/kg CCl_4 exposed group(P<0.01).It is illustrated that the content of serum conjugated bile acids may be a more sensitive indicator to toxic hepatitis than the activity of SGPT.