| 2.4—二硝基苯肼法测定苦杏仁甙及其药物代谢动力学的研究 |
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| 引用本文： | 金泰日,张洛成.2.4—二硝基苯肼法测定苦杏仁甙及其药物代谢动力学的研究[J].延边医学院学报,1989,12(2):89-93. |
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| 作者姓名： | 金泰日 张洛成 |
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| 作者单位： | 延边医学院生物化学教研室，延边医学院生物化学教研室，延边医学院生物化学教研室药学系，延边医学院生物化学教研室，延边医学院生物化学教研室，延边医学院生物化学教研室 84级实习生 |
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| 摘 要： | 本文用2,4-二硝基苯肼法测定了苦杏仁甙,其测定范围为10~(-3)～10~(-2)g/L数量级.给家兔快速静脉注射苦杏仁甙500 mg/kg后,用2,4-二硝基苯肼法分别测定了血药物浓度和尿药物浓度,绘制出浓度-时间曲线,结果得出生物半衰期α/2(分布相)=3.4min;β1/2(消除相)=4.95min;在48h内家兔尿中排泄量为注入剂量的71.4％。
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| 关 键 词： | 苦杏仁甙 药物动力学 |
Assay of Amygdalin Using 2,4-Dinitrophenylhydrazine and Pharmacokinetics of Amygdalin |
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| Jin Tairi,et al.Assay of Amygdalin Using 2,4-Dinitrophenylhydrazine and Pharmacokinetics of Amygdalin[J].Journal of Medical Science Yanbian University,1989,12(2):89-93. |
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| Authors: | Jin Tairi |
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| Institution: | Department of Biochemistry |
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| Abstract: | An amygdalin assay method using 2, 4-dinitrophenylhydrazine was esta- blished. The assay range of amygdalin concentration is 10~(-3)~10~(-2)g/L.Plas- ma amygdalin concentration and urine amygdalin concentration were esti- mated by this assay method after iv injection of 500mg/kg amygdalin into 4 rabbits. The plasma amygdalin decreased in 2 phases with half-lives of 3. 4 and 49. 5 min for the distributive and elirninative phases, respectively. The excretion of the original form of amygdalin in urine within 48 h amounted to 71. 4%. |
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| Keywords: | amygdalin kinetics drugs |
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