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水芹甲醇提取物的抗心律失常与抗脂质过氧化作用
引用本文:张红英,朴惠善.水芹甲醇提取物的抗心律失常与抗脂质过氧化作用[J].延边医学院学报,1993,16(2):134-136.
作者姓名:张红英  朴惠善
作者单位:延边医学院药理学教研室(张红英),延边医学院天然药物化学教研室(金莹),延边医学院附属医院中药局(朴惠善)
摘    要:水芹(Oenanthe stoloniferia DC)甲醇提取物(简称水芹M),对大鼠再灌注所致的心律失常有对抗作用,能够推迟再灌注期间心律失常的开始时间,缩短持续时间,并明显降低再灌注期间室性心律失常的发生率。水芹M(100mg/kg)能明显降低血浆中丙二醛(MDA)含量。提示水芹M对心肌再灌注性损伤有显著的保护作用。

关 键 词:水芹  抗心律失常  丙二醛  大鼠

Anti-arrhythmic and Anti-lipid-peroxidative Effects of Oenathe Stoloniferia DC.
Zhang Hongying Jin Ying Piao Huishan Sha Guilan.Anti-arrhythmic and Anti-lipid-peroxidative Effects of Oenathe Stoloniferia DC.[J].Journal of Medical Science Yanbian University,1993,16(2):134-136.
Authors:Zhang Hongying Jin Ying Piao Huishan Sha Guilan
Abstract:The effects of Oenanthe Stoloniferia DC. were observed by using a model of myocardial ischemia and reperfusion in rats. The results show that Oenanthe Stoloniferia DC. iv. pretreatment prevents arrhythmias induced by myocardial ischemia and reperfusion, and delays the beginning time of arrhythmias during reperfusion period, and shorthes continuous time. It also significantly reduces the incidence of arrhythmias. Oenanthe Stoloniferia DC. (100mg/kg iv.) significantly suppressed the rise of MDA in plasma. The results suggest that Oenanthe Stoloniferia DC. has a protective effect on myocardial injury induced by reperfusion.
Keywords:Oenanthe Stoloniferia DC    arrhythmia  myocardial reperfusion injury  lipid peroxidation  
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