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抑郁模型大鼠大脑和结肠中SOD、MDA和NO含量的异常
引用本文:王玉龙,刘廷毅,董海燕,王高华.抑郁模型大鼠大脑和结肠中SOD、MDA和NO含量的异常[J].中国行为医学科学,2005,14(7):627-628.
作者姓名:王玉龙  刘廷毅  董海燕  王高华
作者单位:华中科技大学同济医学院附属同济医院普外科,山东莒县长岭镇卫生院,武汉大学人民医院消化内科,武汉大学人民医院精神卫生中心 430030
基金项目:美国Stanley Medical Research Institute资助项目(02I-002)
摘    要:目的检测抑郁大鼠模型大脑和结肠组织中SOD、MDA和NO含量,探讨抑郁症大鼠大脑和结肠组织损伤的可能机制。方法建立经典的大鼠抑郁模型。分别采用黄嘌呤氧化酶法、硫代巴比妥酸法及化学方法检测大鼠结肠组织中SOD、MDA和NO的含量。结果抑郁模型大鼠较正常组其大脑和结肠组织中MDA(大脑:10.93±3.32vs2.36±0.91;结肠:10.34±2.77vs2.55±0.70;P<0.01)和NO(大脑:15.15±8.11vs4.07±1.46;结肠:11.28±5.66vs4.76±1.55;P<0.01)含量均显著增加;SOD的含量显著降低(大脑:52.03±8.79vs109.89±26.92;结肠:53.39±11.15vs84.45±22.31;P<0.01)。结论抑郁症对大鼠大脑和结肠组织的损伤可能与氧自由基及NO含量的增加有关。

关 键 词:抑郁模型  过氧化物歧化酶  丙二醛  一氧化氮
修稿时间:2004年12月2日

Effects of depression on SOD,MDA and NO in brain and colon of rat
Wang Yu-long,Liu Ting-yi,Dong Hai-yan,et al..Effects of depression on SOD,MDA and NO in brain and colon of rat[J].Chinese Journal of Behavioral Medical Science,2005,14(7):627-628.
Authors:Wang Yu-long  Liu Ting-yi  Dong Hai-yan  
Institution:Wang Yu-long,Liu Ting-yi,Dong Hai-yan,et al. Department of General Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China
Abstract:ObjectiveTo investigate the effects of depression on the contents of Superoxide dismutase(SOD), Malondialdehyde(MDA) and Nitric oxide(NO) in brain and colon of rats. MethodsSOD, MDA and NO in brain and colon of rat model of depression were detected by biochemistry kits. ResultsEnhanced brain and colon inflammatory response and oxidative stress were observed in the chronic stress-induced depression model of rats, which manifested as the significant increase of MDA and NO levels, while SOD activity was significantly decreased compared with the normal control. ConclusionInjuries on brain and colon of rat model of depression may be induced by increase levels of free oxygen radical and NO in brain and colon.
Keywords:Depression model  Superoxide dismutase  Malondialdehyde  Nitric oxide
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