益气健脾清热解毒中药对肺癌患者化疗间歇期负性情绪及生活质量的影响

目的研究益气健脾清热解毒中药对肺癌患者化疗间歇期负性情绪和生活质量的影响。方法将101例处于化疗间歇期的肺癌患者分为2组,中药组(55例)于化疗间歇期在常规西药对症支持治疗的基础上,加用益气健脾清热解毒法立方进行辨证治疗,对照组(46例)仅以单纯西药对症支持治疗。应用焦虑自评量表(SAS),抑郁自评量表(SDS)以及生活质量核心问卷中文版分别在治疗前后进行负性情绪和生活质量的评定。结果1.治疗后2组患者的焦虑、抑郁负性情绪以及除经济困难以外的其他生活质量各维度均较前有不同程度地改善(P<0.05或P<0.01)。2.中药组治疗后躯体、角色、情绪功能维度和生命质量总评价分(QL)的上升幅度高于对照组(P<0.05或P<0.01),疲乏、恶心呕吐、气促、失眠、和食欲丧失维度以及SAS、SDS总分的减分幅度显著性高于对照组[中药组和对照组减分幅度的比较,SAS为:(6.27±6.92)分vs(3.47±6.32)分;SDS为:(6.33±6.41)分vs(3.89±5.46)分,P<0.05或P<0.01]。3.中药组患者生活质量的功能维度以及除便秘和经济困难因子以外症状维度的改善与SAS、SDS总分减分分值呈正相关(r值为0.29~0.46,P<0.05或P<0.01)。结论化疗间歇期给予益气健脾清热解毒中药干预能改善肺癌患者负性情绪,提高生活质量。

Effects of the Chinese traditional medicines with replenishing spleen qi and clearing away heat and removing toxic substances on negative emotion and quality of life in the lung cancer patients during the intermission stage of the chemotherapy

Objective To explore the effects of the Chinese traditional medicines(CTM) with replenishing spleen qi and clearing away heat and removing toxic substances on negative emotion and quality of life in lung cancer patients during the intermission stage of the chemotherapy.Methods 101 lung cancer patients during the intermission stage of routine chemotherapy were divided into two groups randomly: the CTM group(n=55) with the Chinese traditional medicines of replenishing spleen qi and clearing away heat and removing toxic substances added with the routine western medicines,the control group(n=46) with the routine western medicines only.Both two groups were treated for twenty days.Negative emotion and quality of life were assessed with EORTC QLQ C30,Self-reported Anxiety Scales(SAS) and Self-reported Depression Scales(SDS).Results Both two groups showed that,to some degree,the level of anxiety and depression were decreased and the majority of latitudes of quality of life,except for economic difficulty were improved during the interval stage of chemotherapy(P<0.05,P<0.01).Compared with the control group,there were greater increases in the scores of physical function(PF),role function(RF),emotional function(EF) and global health of life(QL) in the CTM group,and the differences were statistically significant(P<0.05,P<0.01).Greater decreases in fatigue(FA),nausea and vomiting(NV),dyspnoea(DY),insomnia(SL),appetite loss(AP) as well as the scores of SAS and SDS were exhibited in the CTM group(P<0.05,P<0.01).The correlated analysis showed that the degree of improvements of function and symptom latitude,except for constipation and financial difficulty,was positively correlated to the score decreased of SAS and SDS(P<0.05,P<0.01) in the CTM group.Conclusion The Chinese traditional medicines of replenishing spleen qi and clearing away heat and removing toxic substances could relieve negative emotion and improve the quality of life in lung cancer patients during the intervals stage of routine chemotherapy.