| 亚甲蓝原料药的稳定性考察 |
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| 引用本文： | 李莉,汤磊,张敏,黄家宇,张毅.亚甲蓝原料药的稳定性考察[J].贵阳医学院学报,2009,34(3):308-310. |
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| 作者姓名： | 李莉 汤磊 张敏 黄家宇 张毅 |
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| 作者单位： | 贵阳医学院,药学院,贵州,贵阳,550004 |
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| 摘 要： | 目的：考察亚甲蓝原料药的稳定性。方法：亚甲蓝原料药经强光照射（4500 lx）10 d、高温存放（40℃）10 d、高湿存放25℃,RH（75±5）%]10 d、加速试验（40±2）℃,RH（75±5）%]6个月、长期试验1年,考察亚甲蓝原料药经不同条件存放后的性状、含量及有关物质的变化。结果：亚甲蓝原料药经光照试验、高湿试验、高温试验、加速试验和长期试验后,所考察指标均符合质量标准要求。结论：亚甲蓝原料药稳定性较好,但具有吸湿性。
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| 关 键 词： | 亚甲蓝 药物 稳定性 光 温度 湿度 |
Study on the Stability of Methylene Blue |
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| LI Li,TANG Lei,ZHANG Min,HUANG Jiayu,ZHANG Yi.Study on the Stability of Methylene Blue[J].Journal of Guiyang Medical College,2009,34(3):308-310. |
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| Authors: | LI Li TANG Lei ZHANG Min HUANG Jiayu ZHANG Yi |
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| Institution: | (School of Pharmacology, Guiyang Medical College, Guiyang 550004, Guizhou, China) |
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| Abstract: | Objective： To investigate the stability of methylene blue crude materials. Methods： The raw material of methylene blue was treated respectively with highlight （4500Lx, 10d） for 10 days, high temperature （ 40℃ ） for 10 days, high wet （25℃, RH75% ± 5% ）for 10 days, accelerating testing （40℃ ±2℃ RH75% ±5% ）for six months, and a long-term testing of one year, and then the changes of characters, contents of active components and related substances under different storage conditions were observed. Results： All of the tested indexes of the sample were consistent with the quality standards after the series tests. Conclusions： The tested material is stable but is hygroscopicity. |
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| Keywords: | methylene blue drug stability light temperature humidity |
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