贵阳地区1999-2008年炎症性肠病分析

目的:分析贵阳市炎症性肠病(IBD)的临床特征。方法:选择1999年1月～2008年12月收治的IBD患者106例,溃疡性结肠炎(UC)95例,克罗恩病(CD)11例。回顾性记录患者的一般资料、实验室检查、临床表现,比较UC与CD临床资料的差异性。结果:UC住院患者呈上升趋势,CD呈散发;UC及CD患者的平均发病年龄分别为(47.7±16.9)岁、(30.1±14.4)岁(P<0.01);UC及CD吸烟患者分别占20.0%、45.4%,UC患者吸烟时间显著长于CD患者(P<0.01);居住在城镇的UC(80%)患者显著多于CD患者(36.3%),P<0.01;UC及CD发病均主要集中在脑力劳动者(68.4%,72.7%);UC的临床表现以腹泻(80.0%)、体重减轻(38.9%)最为常见,CD以腹痛(90.9%)和贫血(63.6%)最常见;UC住院患者以慢性复发型(62.1%)、中度(60.0%)、直肠乙状结肠炎(33.7%)及活动期(92.7%)最常见,CD以非狭窄非穿通型(54.5%)、结肠型(54.5%)最常见。结论:1999-2008年贵阳市IBD发病呈上升趋势,以UC多见,其临床表现具有地区特征性。

A Retrospective Study on Inflammatory Bowel Diseases in Recent 10 Years in Guiyang City

Objective: To analyze the clinical characteristics of inflammatory bowel diseases(IBD) in Guiyang city retrospectively.Methods: General data,laboratory examination results,and clinical manifestations of 106 patients with IBD including 95 cases of ulcerative colitis(UC) and 11 cases of Crohn’s disease(CD) who received therapy in our hospital from 1999 to 2009 were analyzed retrospectively.The clinical characteristics of UC and CD were compared.Results: The number of UC patients increased in the past 10 years,while CD was sporadic.The mean onset ages of UC and CD were 47.7±16.9 year old and 30.1±14.4 year old respectively(P<0.01).The percentage of smokers in UC and CD were 20.0% and 45.4% respectively,and smoking duration in UC was longer than that in DC(P<0.01).The number of UC lived in urban area(80%) was more than that of CD(36.3%)(P<0.01).Both UC and CD mainly happened in mental workers(68.4% VS 72.7%).The main clinical manifestations of UC were diarrhea(80.0%) and weight loss(38.9%).Those of CD were abdominal pain(90.9%) and anemia(63.6%).Chronic relapse(62.1%,59/95),moderate(60.0%,57/95),proctosigmoiditis(33.7%,32/95),and active(92.7%,88/95) types were most common in UC.while non-stricturing/non-penetrating(54.5%,6/11) types were most common in CD,and lesions commonly located at colon(54.5%,6/11).Conclusions: In Guiyang,the number of IBD patients,specially UC patients,shows an increasing tendency in recent 10 years.The clinical manifestations of IBD have area characteristics.