西酞普兰及其代谢物的对映体稳态血药浓度

测定了16例老年抑郁症患者口服西酞普兰(Citalopram，CIT)后CIT及其代谢物对映体的稳态波谷血药浓度。结果表明，口服20 mg／d后(n=14)，R-CIT和S-CIT的平均稳态浓度分别为(36．2±15．0)μg/L和(27．4±13．1)μg/L，R-DM-CIT和S-DM-CIT分别为(7．2±3．1)μg/L和(7．7±3．8)μg/L；口服40 mg/d后(n=2)，CIT和去甲西酞普兰(DM-CIT)浓度有高于前者的趋势；去二甲西酞普兰(DDM-CIT)仅在8例患者中测出R-DDM-CIT。R-CIT与S-CIT，R-DM-CIT与S-DM-CIT以及R-CIT与R-DDM-CIT间存在线性正相关。

Analysis of State Plasma Concentrations of Enantiomers of Citalopram and its Metabolites in Elder Patients

In this paper the state plasma concentrations of enantiomers of citalopram and its/metabolites in 16 elder depressive patients were determined by a stereoselective HPLC method./The result showed that for the dose of 20 mg per day ( n = 12) the mean values ±SD of R-CIT and SCIT plasma concentrations were (36.2 + 15.0) μg/L and (27.4 + 13.1) μg/L respectively, for R - (and S- DM- CIT) (7.2 + 3.1) μg/L and (7.7 + 3.8) μg/L respectively, whereas DDM - CIT was only detectable as R - enantiomer in 8 cases. For the dose of 40 mg per day, there was seemly a tendency of higher plasma concentrations of CIT and its metabolites than the former with lower dose. Significant (P < 0.01) linear correlation could be found between both enantiomers of CIT and DM - CIT as well as between the parent drug and primary metabolite for Renantiomer.