| 替莫唑胺对高级别脑胶质瘤疗效的Meta分析 |
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| 引用本文： | 王耀伍,尹春丽,张志勇,张宏义,张坤,张志民,廖珩.替莫唑胺对高级别脑胶质瘤疗效的Meta分析[J].山东大学学报(医学版),2012,50(6):80-82,86. |
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| 作者姓名： | 王耀伍 尹春丽 张志勇 张宏义 张坤 张志民 廖珩 |
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| 作者单位： | 1. 唐山市工人医院神经外科,河北唐山,063000
2. 石家庄以岭医院神经外科,石家庄,050000 |
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| 摘 要： | 目的比较不同治疗药物在高级别脑胶质瘤手术治疗后的效果,分析评价替莫唑胺的疗效。方法利用文献检索方法收集国内使用替莫唑胺治疗高级别脑胶质瘤的文献,对符合入选条件的文献,应用Stata软件中的Me-ta程序分析替莫唑胺对高级别脑胶质瘤的疗效。结果入选文献7篇,共纳入病例438例,其中治疗组227例,对照组211例。Meta分析结果显示,合并OR值为3.70,95%可信区间为2.37～5.79,Mantel-Haenszel的固定效应模型检验结果 Z=5.75,P<0.01,表明替莫唑胺的总体疗效显著高于其他同类药物。结论替莫唑胺可作为当前阶段治疗高级别脑胶质瘤首选药物。
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| 关 键 词： | 高级别脑胶质瘤 替莫唑胺 Meta分析 |
Meta-analysis of temozolomide for high-grade gliomas |
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| WANG Yao-wu
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YIN Chun-li
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ZHANG Zhi-yong
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ZHANG Hong-yi
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ZHANG Kun
,
ZHANG Zhi-min
,
LIAO Heng.Meta-analysis of temozolomide for high-grade gliomas[J].Journal of Shandong University:Health Sciences,2012,50(6):80-82,86. |
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| Authors: | WANG Yao-wu YIN Chun-li ZHANG Zhi-yong ZHANG Hong-yi ZHANG Kun ZHANG Zhi-min LIAO Heng |
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| Institution: | 1(1.Department of Neurosurgery,Tangshan Gongren Hospital,Tangshan 063000,Hebei,China;2.Department of Neurosurgery,Shijiazhuan yiling Hospital,Shijiazhang 050000,Hebei,China) |
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| Abstract: | Objective To compare and evaluate the effects of temozolomide and other drugs in the high-grade gliomas post-surgical treatment.Methods In this literature review study,papers on temozolomide for high-grade gliomas were collected and Meta-analysis was performed using Stata software.Results 7 papers were included.Of 438 patients,227 were in the treatment group and 211 were in the control group.The Meta analysis results showed that M-H pooled OR was 3.70 and 95% CI was 2.37-5.79,while the Mantel-Haenszel test showed that Z was 5.75 and P < 0.01,which indicated the effects of temozolomide was significantly better than other drugs.Conclusion At present,temozolomide can be used as the drug of choice for high-grade gliomas. |
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| Keywords: | High-grade gliomas Temozolomide Meta analysis |
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