FOXP3在玫瑰糠疹、扁平苔藓、大斑块型副银屑病及蕈样肉芽肿中的表达及意义

目的探讨叉头状转录因子P3(FOXP3)在玫瑰糠疹、扁平苔藓、大斑块型副银屑病及蕈样肉芽肿中的表达及意义。方法采用免疫组织化学EnVision法检测21例玫瑰糠疹、19例扁平苔藓、17例大斑块型副银屑病、22例蕈样肉芽肿及10例正常人皮肤中FOXP3的表达。结果玫瑰糠疹、扁平苔藓皮损中FOXP3+淋巴细胞阳性率与正常人皮肤中的表达差异无统计学意义(P>0.05);大斑块型副银屑病与蕈样肉芽肿皮损中FOXP3+淋巴细胞阳性率均高于玫瑰糠疹、扁平苔藓及正常皮肤(P<0.05),但其二者之间的表达差异无统计学意义(P>0.05)。结论 FOXP3+淋巴细胞阳性率在炎症性皮肤病、有肿瘤发展倾向的炎症性皮肤病及皮肤淋巴瘤中的表达有逐步增高的趋势。其增多可能为肿瘤细胞的免疫逃逸提供了条件,进而促进了肿瘤的发生、发展。

Expression and significance of FOXP3 in pityriasis rosea,lichen planus,large-plaque parapsoriasis and mycosis fungoides

Objective To investigate expression and significance of fork-head box protein-3(FOXP3) in normal skins,pityriasis rosea,lichen planus,large-plaque parapsoriasis,and mycosis fungoides.Methods The immunohistochemical EnVision method was applied to detect expression of FOXP3 in 21 cases of pityriasis rosea,19 cases of lichen planus,17 cases of large-plaque parapsoriasis,22 cases of mycosis fungoides,and 10 normal skin controls.Results Rates of FOXP3-positive lymphocytes in lesions of pityriasis rosea and lichen planus had no significant difference compared with normal skin(P>0.05).Rates of FOXP3-positive lymphocytes in lesions of large-plaque parapsoriasis and mycosis fungoides were higher than those in pityriasis rosea,lichen planus,and normal skin(P<0.05),while no significant difference was found between large-plaque parapsoriasis and mycosis fungoides(P>0.05).Conclusions FOXP3-positive lymphocytes show a gradual increasing tendency in inflammatory skin diseases,tumor tendency inflammatory skin diseases and cutaneous lymphoma.They may play an important role in immune escape of tumors and promote tumor occurrence and development.