急性颅脑损伤患者下丘脑垂体激素变化的临床意义

目的:探讨急性颅脑损伤患者下丘脑及垂体前叶功能改变及其临床意义。方法:随机选取急性颅脑损伤住院患者50例,测定垂体激素TSH、FSH、LH、PRL及GH的基础值及动态变化进行分组研究,并设立对照组,对结果进行统计分析。结果:急性颅脑损伤患者下丘脑及垂体前叶功能与对照组相比改变明显(P<0.05)。颅脑损伤程度越重,伤后即刻垂体激素值越高,而动态观察则逐渐下降,多数可降至正常值以下。结论:急性颅脑损伤患者伤后垂体激素的基础值和动态变化值可以作为伤情评价和判断预后的重要指标。

Dynamic of hypothalamic-pituitary hormones in patients with acute craniocerebral injury and its clinical significance

Objective: To study the functional change of hypothalamus and pituitary in patients with acute craniocerebral injury and its clinical significance. Methods: Fifty patients with acute craniocerebral injury were randomly chosen to test their pituitary hormones of TSH, FSH, LH, PRL and GH. A control group was set up and the data of the two groups were analyzed. Results: The function of hypothalamic-pituitary in acute craniocerebral injury patients was changed remarkably compared to that of the controls (P<0.05). The more severe the craniocerbral injury, the higher the volume of pituitary hormone immediately after injury. And the levels were gradually decreased, most of which came to a point that was below normal. Conclusion: Basal volume and dynamic of pituitary hormones in patients immediately after acute craniocerebral injury could serve as a guideline for judging the injury degree and prognosis.