子宫腺肌病动物模型研究进展

子宫腺肌病是指子宫内膜(包括腺体和间质)侵入子宫肌层生长产生的病变;主要临床症状包括月经过多、严重痛经和不孕,对患者身心健康造成很大的影响。子宫腺肌病好发于育龄期女性,但因其病因尚不明确,缺乏敏感特异的诊断办法,且治疗手段有限,导致了目前亟需对发病机制、特征性诊断、针对性治疗的深入研究。动物模型的建立及应用对上述问题的解决具有重要意义。目前研究表明子宫腺肌病非人类特有,故有可选择的实验动物,且多种雌性动物的生殖系统与人类女性生殖系统具有相似性,有利于开展机制方面的研究。就子宫腺肌病动物模型建立及应用进行综述。

Research progress of animal models of adenomyosis

Adenomyosis refers to the pathological changes caused by the invasion of endometrium (including glands and stroma) into the myometrium. The main clinical symptoms include menorrhagia, severe dysmenorrhea and infertility, which have a serious impact on the physical and mental health of patients. Adenomyosis often occurs in women of childbearing age, but its etiology remains unclear. There is still no specific diagnostic method, and the treatment methods are limited. Researches on the pathogenesis, characteristic diagnosis and targeted treatment are urgently needed. The establishment and application of animal models are significant to solve the above problems since many studies have shown that adenomyosis is not unique to humans. The alternative experimental animals have reproductive system similar to that of human women, which is conducive to the study of mechanism. This paper reviews the establishment and application of animal model of adenomyosis.