通心络与辛伐他汀稳定兔易损斑块的疗效对比

目的对比研究通心络与辛伐他汀对兔易损斑块的稳定作用。方法30只实验兔采用球囊拉伤腹主动脉+高脂喂养建立动脉粥样硬化模型，10周末改喂普通饲料并随机分为自然消退组、通心络组、辛伐他汀组，每组10只，持续药物干预12周，22周末斑块局部转染携带p53的复制缺陷型重组腺病毒载体，24周末，应用蝰蛇毒、组胺触发。检测血脂并进行体表超声、声学密度和病理学检测。结果通心络组和辛伐他汀组与自然消退组比较，血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)（P＜0.01）、腹主动脉内中膜厚度（IMT）（P＜0.05，P＜0.01）均显著降低；内 中膜校正回声强度（AIIc %）显著升高（P＜0.05～0.01）。辛伐他汀组与通心络比较，TC水平降低（P＜0.01）。结论通心络和辛伐他汀一样具有稳定易损斑块的作用，且疗效相当。

Effects of Tongxinluo and Simvastatin on vulnerable plaques in rabbits: a comparison study

Objective To compare the stabilizing effects of Tongxinluo and Simvastatin on vulnerable plaques in rabbits.Methods 30 rabbits were subjected to balloon-induced abdominal aortic wall injuries and then were fed with a diet of 1% cholesterol.After 10 weeks induction,they were randomly divided into three groups:the regression group,the Tongxinluo group and the simvastatin group.At the end of week 24,recombinant-p53 adenoviruses were locally delivered to the atherosclerotic plaques and plaque rupture was triggered by intra-arterial viper venom and histamine.The serum lipids,the high frequency duplex,the acoustic densitometry and the pathologic staining were all determined.Results Compared with the regression group,TC,LDL-C(P<0.01)and IMT(P<0.05-0.01)in the Tongxinluo group and the Simvastatin group were significantly decreased while the AIIc %(P<0.05-0.01)was significantly increased.The TC level in the Simvastatin group was lower than that in the Tongxinluo group(P<0.01).Conclusion Both Tongxinluo and Simvastatin can increase the stability of atherosclerosis in rabbits with vulnerable plaques.