对非酒精性脂肪肝患者生活方式干预的效果评价

目的 评估生活方式干预对非酒精性脂肪肝患者的治疗效果。方法 对105名非酒精性脂肪肝患者实施生活方式干预，包括健康教育、饮食干预与运动干预。根据超声诊断标准，将脂肪肝分为轻、中、重度3组，其中轻度组64人，中度组35人，重度组6人，并采用氯化酶法检测患者的血脂指标包括甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL），12个月后复查超声及血脂指标，对其效果进行分析评估。结果 干预后，轻度组中有40人消除脂肪肝（P＜0.01）；中度组中有28人转变成轻度脂肪肝,有3人消除脂肪肝（P＜0.01）；重度脂肪肝中有3人转变成中度脂肪肝（P＜0.05）；干预后TG 、TC、 LDL较干预前降低（P＜0.05）。结论 对非酒精性脂肪肝患者进行生活方式干预，可降低脂肪肝的发病率，提高脂肪肝的逆转率。

Effectiveness of lifestyle intervention in non-alcoholic fatty liver disease

Objective    To evaluate therapeutic effectiveness of lifestyle intervention in non-alcoholic fatty liver disease. Methods    105 cases of  non-alcoholic fatty liver patients were enrolled.  Lifestyle interventions was applied to all of them, including learning knowledge of health, dietary control and exercises .There were 64 mild ,35 moderate  and 6 severe cases  diagnosed by ultrasonic tomography. Triglyceride (TG), total cholesterol（TC）, HDL-cholesterol (HDL) and LDL-cholesterol(LDL) were also measured. After 12 months of therapy, the effectiveness was finally evaluated. Results    After 12-month lifestyle intervention, 40 mild fatty liver recovered to normal（P＜0.01) while among moderate cases, 28 turned into mild and 3 recovered to normal（P＜0.01). 3 severe cases became moderate（P＜0.05）. And TG、TC、LDL decreased significantly. Conclusion    Lifestyle intervention can effectively reduce the morbidity rate and increase the recovery rate in non-alcoholic fatty liver patients.